Original contributionThe efficacy of single-dose aprotinin 2 million KIU in reducing blood loss and its impact on the incidence of deep venous thrombosis in patients undergoing total hip replacement surgery☆
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Cited by (46)
Efficacy and safety of systemic tranexamic acid administration in total knee arthroplasty: A case series
2020, International Journal of Surgery Case ReportsUse of aprotinin to reduce blood loss and transfusion in major orthopedic surgery: A meta-analysis
2014, Transfusion and Apheresis ScienceCitation Excerpt :A total of 1276 patients were enrolled in the randomized controlled trials. Nine studies involved hip surgery [11–19], three studies involved spinal surgery [20–22], two studies involved knee surgery [23,24] and four studies involved other surgery [25–28]. The number of patients included in these randomized controlled trials ranged from 17 to 352.
Use of antifibrinolytic therapy to reduce transfusion in patients undergoing orthopedic surgery: A systematic review of randomized trials
2009, Thrombosis ResearchCitation Excerpt :Differences in surgical techniques and transfusion thresholds are likely to have contributed to the differences observed between studies. Lastly, estimating blood loss was variable, since blood due to hematomas [57] or tissue extravasation [77] were rarely measured and only 5[51,55,57,60,70] studies used a method to account for this source of blood loss. Few studies reported the type of surgical hemostasis (i.e., electrical cauterization, tissue adhesives) utilized; these techniques are known to reduce blood loss during surgery [70].
The Use of Antifibrinolytic Agents in Total Hip Arthroplasty. A Meta-analysis
2006, Journal of ArthroplastyTransfusion avoidance in orthopedic surgery
2004, Journal of Cardiothoracic and Vascular Anesthesia
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Supported in part by a grant from the Cappagh Hospital Trust, Dublin, Ireland.
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Registrar in Anaesthesia.
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Consultant in Anaesthesia.