Effects of indomethacin on biologic fixation of porous-coated titanium implants
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Osseointegration Pharmacology: A Systematic Mapping Using Artificial Intelligence
2021, Acta BiomaterialiaCitation Excerpt :These studies used porous-coated chrome-cobalt implants, cylindrical titanium implants, and screw implants, respectively, and the analyzed bone-implant contact, bone ingrowth, and push-out force. On the other hand, pre-operative, and post-operative administration of indomethacin (1 and 4 mg/kg/day, SC, Oral) did not show any effect on osseointegration in a study on rabbits and another one on dogs [198, 199]. These studies used cylindrical titanium implants, and they assessed bone-implant contact and peri-implant bone density.
Mode III cleavage of a coin-shaped titanium implant in bone: Effect of friction and crack propagation
2012, Journal of the Mechanical Behavior of Biomedical MaterialsCitation Excerpt :Many of these studies are of limited interest to understand the basic biomechanical phenomena responsible for implant stability due to the complex implants geometry. Most studies on bone attachment of titanium implants have focused on the effect of shear forces using push out (Ogiso et al., 1998; Vercaigne et al., 1998), pull out (Berzins et al., 1997; Cook et al., 1995; Giavaresi et al., 2003; Jinno et al., 1998; Soncini et al., 2002) or torque test (Branemark et al., 1997, 1998; Branemark and Skalak, 1998). The geometrical properties of implants influence the results of biomechanical test results (Branemark et al., 1998), leading to spatially complex, nonuniform, multiaxial stress fields at the loaded interface (Shirazi-Adl, 1992).
Biocompatibility of engineered soft tissue created by stem cells
2010, Biointegration of Medical Implant Materials: Science and DesignIs there an inhibitory effect of COX-2 inhibitors on bone healing?
2004, Pharmacological Research