Role of chance in familial aggregation of colorectal cancer

N Katballe; S M Bentzen; M Christensen; F P Wikman; T Ørntoft; S Laurberg

doi:10.1054/bjoc.2000.1717

Role of chance in familial aggregation of colorectal cancer

Br J Cancer. 2001 Apr 20;84(8):1084-6. doi: 10.1054/bjoc.2000.1717.

Authors

N Katballe¹, S M Bentzen, M Christensen, F P Wikman, T Ørntoft, S Laurberg

Affiliation

¹ Surgical Research Unit 900, Department or Surgery L, Aarhus University Hospital, Aarhus Amtssygehus, Aarhus, Denmark.

Abstract

A prospective population-based study recorded family trees of 77 colorectal cancer patients younger than 50 years of age. Using mathematical modeling of population age-incidence data, we estimate that 1 (95% confidence limits 0 and 3) of these families is expected to meet the Amsterdam criteria I for HNPCC due to chance clustering of colorectal cancer.

Publication types

Multicenter Study
Research Support, Non-U.S. Gov't

MeSH terms

Colorectal Neoplasms, Hereditary Nonpolyposis / genetics*
Denmark
Family Health
Female
Humans
Male
Middle Aged
Probability
Prospective Studies