Purpose: We present a case of severe diarrhea caused by lymphocytic colitis and concurrent celiac sprue in a patient who did not respond to maximal medical therapy and required surgery.
Methods: The patient was initially treated with fecal diversion via an end ileostomy. Six months later, she underwent colectomy and one-stage ileal J-pouch-anal anastomosis.
Results: Notably, the characteristic microscopic changes of lymphocytic colitis were still present at the time of colectomy despite diversion.
Conclusion: Colectomy with continent reconstruction is an option for treatment of patients with lymphocytic colitis refractory to medical therapy.