Abstract
Stimulated pancreatic and biliary outputs were studied in seven healthy subjects during intravenous infusion of bovine pancreatic polypeptide (P.P.) (mean dose 65 pmol/kg/h). P.P. significantly inhibited outputs of trypsin and bilirubin at plasma concentrations similar to those observed after meals. In four cholecystectomised subjects, P.P. inhibited only trypsin output.
MeSH terms
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Adult
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Aged
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Animals
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Bicarbonates / antagonists & inhibitors
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Bilirubin / antagonists & inhibitors
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Bilirubin / metabolism*
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Cattle
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Eating
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Gallbladder / drug effects*
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Gallbladder / physiopathology
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Hormones / administration & dosage
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Hormones / blood
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Hormones / pharmacology
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Humans
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Infusions, Parenteral
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Middle Aged
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Pancreas / drug effects*
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Pancreas / enzymology
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Pancreas / metabolism
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Pancreatic Polypeptide / administration & dosage
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Pancreatic Polypeptide / blood
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Pancreatic Polypeptide / pharmacology*
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Trypsin / metabolism*
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Trypsin Inhibitors*
Substances
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Bicarbonates
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Hormones
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Trypsin Inhibitors
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Pancreatic Polypeptide
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Trypsin
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Bilirubin