Background Approaches to removal of sedation and mechanical ventilation for critically ill
patients vary widely. Our aim was to assess a protocol that paired spontaneous awakening …

Study objectives: The goal of this study was to determine whether the survival of patients
with pulmonary hypertension related to systemic sclerosis (SScPH) was different from that of …

The International Committee of Medical Journal Editors (ICMJE) believes that there is an
ethical obligation to responsibly share data generated by interventional clinical trials because …

The International Committee of Medical Journal Editors (ICMJE) believes there is an ethical
obligation to responsibly share data generated by interventional clinical trials because trial …

… Author links open overlay panel Darren B. Taichman MD, PhD, FCCP a , Joe Ornelas MS
b , Lorinda Chung MD c , James R. Klinger MD, FCCP d , Sandra Lewis PhD …

Portopulmonary hypertension affects up to 6% of patients with advanced liver disease, but
the predictors and biologic mechanism for the development of this complication are unknown. …

Background— Nearly all available treatments for pulmonary arterial hypertension have been
approved based on change in 6-minute walk distance (Δ6MWD) as a clinically important …

Background Pulmonary arterial hypertension (PAH) is typically distinguished from pulmonary
venous hypertension (PVH) by documenting a pulmonary capillary wedge pressure (PCWP…

Rationale: Portopulmonary hypertension (PPHTN) occurs in 6% of liver transplant candidates.
The pathogenesis of this complication of portal hypertension is poorly understood. …

Background Improved outcomes with expanding treatment options for patients with
pulmonary arterial hypertension present the opportunity to consider additional end-points in …