User profiles for Hala Muaddi

Hala Muaddi

MD, MSc, PhD, FRCSC
Verified email at mail.utoronto.ca
Cited by 1331

Clinical outcomes of robotic surgery compared to conventional surgical approaches (laparoscopic or open): a systematic overview of reviews

H Muaddi, M El Hafid, WJ Choi, E Lillie… - Annals of …, 2021 - journals.lww.com
Objective: Describe clinical outcomes (eg, postoperative complications, survival) after robotic
surgery compared to open or laparoscopic surgery. Background: Robotic surgery utilization …

The impact of negative pressure wound therapy for closed surgical incisions on surgical site infection: a systematic review and meta-analysis

J Shiroky, E Lillie, H Muaddi, M Sevigny, WJ Choi… - Surgery, 2020 - Elsevier
Background Surgical site infections cause substantial morbidity and mortality. Negative
pressure wound therapy may reduce the risk of surgical site infections, but current evidence is …

[HTML][HTML] The new era of transplant oncology: liver transplantation for nonresectable colorectal cancer liver metastases

A Gorgen, H Muaddi, W Zhang, I McGilvray… - Canadian Journal of …, 2018 - hindawi.com
Colorectal cancer (CRC) is the third most incident cancer worldwide. Most of CRC patients
will develop distant metastases, mainly to the liver, and liver resection is the only potential …

Reprogramming metabolism with metformin improves tumor oxygenation and radiotherapy response

VE Zannella, A Dal Pra, H Muaddi, TD McKee… - Clinical cancer …, 2013 - AACR
Purpose: Tumor hypoxia is a negative prognostic factor in multiple cancers, due in part to its
role in causing resistance to radiotherapy. Hypoxia arises in tumor regions distal to blood …

Phosphorylation of eIF2α at serine 51 is an important determinant of cell survival and adaptation to glucose deficiency

H Muaddi, M Majumder, P Peidis… - Molecular biology of …, 2010 - Am Soc Cell Biol
Various forms of stress induce pathways that converge on the phosphorylation of the alpha (α)
subunit of eukaryotic translation initiation factor eIF2 at serine 51 (S51), a modification that …

Outcomes of radiofrequency ablation as first-line therapy for hepatocellular carcinoma less than 3 cm in potentially transplantable patients

A Doyle, A Gorgen, H Muaddi, AD Aravinthan… - Journal of …, 2019 - Elsevier
Background & Aims Radiofrequency ablation (RFA) is an effective treatment for single
hepatocellular carcinoma (HCC) ≤3 cm. Disease recurrence is common, and in some patients …

eIF2α Kinase PKR modulates the hypoxic response by Stat3-dependent transcriptional suppression of HIF-1α

AI Papadakis, E Paraskeva, P Peidis, H Muaddi, S Li… - Cancer research, 2010 - AACR
Hypoxia within the tumor microenvironment promotes angiogenesis, metabolic reprogramming,
and tumor progression. In addition to activating hypoxia-inducible factor-1α (HIF-1α), …

Association between social determinants of health and rates of liver transplantation in individuals with cirrhosis

JA Flemming, H Muaddi, M Djerboua, P Neves… - …, 2022 - Wiley Online Library
Background and Aims This study evaluated the association between neighborhood‐level
social determinants of health (SDOH) and liver transplantation (LT) among patients with …

Safety and feasibility of initiating a hepatic artery infusion pump chemotherapy program for unresectable colorectal liver metastases: A multicenter, retrospective cohort …

H Muaddi, M D'Angelica, JT Wiseman… - Journal of surgical …, 2021 - Wiley Online Library
Introduction Hepatic artery infusion pump (HAIP) chemotherapy is a specialized therapy for
patients with unresectable colorectal liver metastases (uCRLM). Its effectiveness was …

[HTML][HTML] The management of post-transplantation recurrence of hepatocellular carcinoma

…, T Ivanics, MPAW Claasen, H Muaddi… - Clinical and …, 2022 - ncbi.nlm.nih.gov
The annual incidence of hepatocellular carcinoma (HCC) continues to rise. Over the last
two decades, liver transplantation (LT) has become the preferable treatment of HCC, when …