Background Appropriate screening may reduce the mortality and morbidity of colorectal,
breast, and cervical cancers. However, effective implementation strategies are warranted if the …

Almost 7 % of breast cancers are diagnosed among women age 40 years and younger in
Western populations. Clinical outcomes among young women are worse. Early age-of-onset …

Rare copy-number variation (CNV) is an important source of risk for autism spectrum
disorders (ASDs). We analyzed 2,446 ASD-affected families and confirmed an excess of genic …

Using a multistage genetic association approach comprising 7,480 affected individuals and
7,779 controls, we identified markers in chromosomal region 8q24 associated with colorectal …

We conducted a two-stage genome-wide association study of pancreatic cancer, a cancer
with one of the lowest survival rates worldwide. We genotyped 558,542 SNPs in 1,896 …

In an analysis of 31,717 cancer cases and 26,136 cancer-free controls from 13 genome-wide
association studies, we observed large chromosomal abnormalities in a subset of clones in …

Background Iron has been shown to promote breast carcinogenesis in animal models through
generation of oxidative stress and interaction with estrogen. Heme iron, which is found …

We conducted a genome-wide association study of pancreatic cancer in 3,851 affected
individuals (cases) and 3,934 unaffected controls drawn from 12 prospective cohort studies and …

Background To evaluate the dose–response relationship between cigarette smoking and
pancreatic cancer and to examine the effects of temporal variables. Methods We analyzed data …

… M. Cotterchio and N. Kreiger are affiliated with the Department of Public Health Sciences, …
Cotterchio, and N. Kreiger are affiliated with Cancer Care Ontario, Toronto, ON, Canada …