We developed a systematic approach to map human genetic networks by combinatorial
CRISPR–Cas9 perturbations coupled to robust analysis of growth kinetics. We targeted all pairs …

… up ineluctably in the young Beckett. We who love to read Beckett can scarcely imagine that
his writerly destiny was not early apparent. Although the mature Beckett told me that there …

Helicobacter pylori VacA is a channel-forming toxin unrelated to other known bacterial toxins.
Most H. pylori strains contain a vacA gene, but there is marked variation among strains in …

Global dispersal and increasing frequency of the SARS-CoV-2 spike protein variant D614G
are suggestive of a selective advantage but may also be due to a random founder effect. We …

BACKGROUND: Mosquito bite–induced acute systemic allergic reactions are an increasing
clinical concern and have not been optimally characterized immunologically. OBJECTIVE: …

This Fourth Edition has been thoroughly revised and updated to take account of international
developments in pharaceutical chemistry and to maintain the position of Practical …

Objective To evaluate the effects of therapeutic heparin compared with prophylactic heparin
among moderately ill patients with covid-19 admitted to hospital wards. Design Randomised …

Background The SARS-CoV-2 variant B.1.1.7 was first identified in December, 2020, in
England. We aimed to investigate whether increases in the proportion of infections with this …

Damage control resuscitation (DCR) is a strategy for resuscitating patients from hemorrhagic
shock to rapidly restore homeostasis. Efforts are focused on blood product transfusion with …

Deregulation and the emergence of new forms of technology have created highly competitive
market conditions which have had a critical impact upon consumer behaviour. Bank …