The surface potential of biological membranes varies according to their lipid composition.
We devised genetically encoded probes to assess surface potential in intact cells. These …

The hypothesis that epithelial–mesenchymal transition (EMT) might be a contributor to the
accumulation of fibroblasts and myofibroblasts (MFs) in the kidney during fibrogenesis was …

Cortactin, an actin filament-binding protein and target of multiple kinases, has emerged as a
central element connecting signaling pathways with cytoskeleton restructuring. It is involved …

Electrostatic interactions with negatively charged membranes contribute to the subcellular
targeting of proteins with polybasic clusters or cationic domains. Although the anionic …

Pre–B cell colony-enhancing factor (PBEF) is a highly conserved 52-kDa protein, originally
identified as a growth factor for early stage B cells. We show here that PBEF is also …

Like many organs, the kidney stiffens after injury, a process that is increasingly recognized
as an important driver of fibrogenesis. Yes-associated protein (YAP) and transcriptional …

In pressure or volume overload, hypertrophic growth of the myocardium is associated with
myofibroblast differentiation, a process in which cardiac fibroblasts express smooth muscle α-…

New research suggests that, during tubulointerstitial fibrosis, α-smooth muscle actin (SMA)-expressing
mesenchymal cells might derive from the tubular epithelium via epithelial-…

Expansion on stiff culture substrates activates pro-fibrotic cell programs that are retained by
mechanical memory. Here, we show that priming on physiologically soft silicone substrates …

Objective: The resolution of neutrophil (PMN)-mediated inflammation occurs through the
apoptosis, or programmed cell death, of the neutrophil. PMN apoptosis is inhibited by a variety …