Interactions between the microbiota and the immune system

LV Hooper, DR Littman, AJ Macpherson - science, 2012 - science.org
The large numbers of microorganisms that inhabit mammalian body surfaces have a highly
coevolved relationship with the immune system. Although many of these microbes carry out …

Immune adaptations that maintain homeostasis with the intestinal microbiota

LV Hooper, AJ Macpherson - Nature Reviews Immunology, 2010 - nature.com
Humans harbour nearly 100 trillion intestinal bacteria that are essential for health. Millions of
years of co-evolution have moulded this human–microorganism interaction into a symbiotic …

Interactions between commensal intestinal bacteria and the immune system

AJ Macpherson, NL Harris - Nature Reviews Immunology, 2004 - nature.com
Although we might shudder at the thought of billions of bacteria living in our lower intestine,
we are colonized by these passengers shortly after birth. However, the relationship is mostly …

PREPARATION AND PHOTOPHYSICAL STUDIES OF PORPHYRIN‐C60 DYADS

PA Liddell, JP Sumida, AN Macpherson… - Photochemistry and …, 1994 - Wiley Online Library
Porphyrin‐C 60 dyads in which the two chromophores are linked by a bicyclic bridge have
been synthesized using the Diels‐Alder reaction. The porphyin singlet lifetimes of both the …

Direct detection of singlet oxygen from isolated photosystem II reaction centres

AN Macpherson, A Telfer, J Barber… - Biochimica et Biophysica …, 1993 - Elsevier
Both steady-state and time-resolved luminescence measurements at 1270 nm indicate that,
when illuminated, isolated reaction centres of Photosystem II can generate singlet oxygen, O …

Solvent Dependence of the Ultrafast S2−S1 Internal Conversion Rate of β-Carotene

AN Macpherson, T Gillbro - The Journal of Physical Chemistry A, 1998 - ACS Publications
The solvent dependence of the steady-state and time-resolved fluorescence emission from
the S 2 (1 1 B u ) state of all-trans-β-carotene was investigated in a range of polar and …

Association between insertion mutation in NOD2 gene and Crohn's disease in German and British populations

…, H Frenzel, K King, A Hasselmeyer, AJS MacPherson… - The Lancet, 2001 - thelancet.com
Background Genetic predisposition to inflammatory bowel disease (IBD) has been shown
by epidemiological and linkage studies. Genetic linkage of IBD to chromosome 16 has been …

Induction of protective IgA by intestinal dendritic cells carrying commensal bacteria

AJ Macpherson, T Uhr - Science, 2004 - science.org
The enormous number of commensal bacteria in the lower intestine of vertebrates share
abundant molecular patterns used for innate immune recognition of pathogenic bacteria. We …

Bridge-dependent electron transfer in porphyrin-based donor− bridge− acceptor systems

K Kilså, J Kajanus, AN Macpherson… - Journal of the …, 2001 - ACS Publications
Photoinduced electron transfer in donor−bridge−acceptor systems with zinc porphyrin (or its
pyridine complex) as the donor and gold(III) porphyrin as the acceptor has been studied. …

[HTML][HTML] Salmonella enterica serovar typhimurium exploits inflammation to compete with the intestinal microbiota

…, M Barthel, M Kremer, S Chaffron, AJ Macpherson… - PLoS …, 2007 - journals.plos.org
Most mucosal surfaces of the mammalian body are colonized by microbial communities (“microbiota”).
A high density of commensal microbiota inhabits the intestine and shields from …