Traditional screening paradigms often focus on single targets. To facilitate drug discovery in
the more complex physiological environment of a cell or organism, powerful cellular imaging …

Carvedilol is a potent antihypertensive agent with a dual mechanism of action. At relatively
low concentrations it is a competitive β-adrenoceptor antagonist and a vasodilator, whereas …

Mitogen‐activated protein (MAP) kinases are important players in signal transduction pathways
activated by a range of stimuli and mediate a number of physiological and pathological …

Background: This document provides clinical recommendations for the diagnosis of
idiopathic pulmonary fibrosis (IPF). It represents a collaborative effort between the American …

Stimulated CD4+ T lymphocytes can differentiate into effector T cell (Teff) or inducible
regulatory T cell (Treg) subsets with specific immunological roles. We show that Teff and Treg …

Here we report that in staurosporine-induced apoptosis of HeLa cells, Bid, a BH3 domain
containing protein, translocates from the cytosol to mitochondria. This event is associated with …

Human angiotensin-converting enzyme-related carboxypeptidase (ACE2) is a zinc
metalloprotease whose closest homolog is angiotensin I-converting enzyme. To begin to elucidate …

Crystalline silica (mostly cristobalite) was produced by vapor-phase crystallization and
devitrification in the andesite lava dome of the Soufriere Hills volcano, Montserrat. The sub–10-…

It is now widely recognised that learning a language should not just involve linguistic competence
but also intercultural competence. It is also clear that intercultural competence can be …

CD4 T cell activation leads to proliferation and differentiation into effector (Teff) or regulatory
(Treg) cells that mediate or control immunity. While each subset prefers distinct glycolytic or …