Background & Aims The medical management of ulcerative colitis (UC) has improved through
the development of new therapies and novel approaches that optimize existing drugs. …

Background The efficacy of corticosteroids in the setting of maintenance therapy for Crohn's
disease has never been clearly demonstrated. It would be important to determine, based …

Background Corticosteroids play a key role in the induction of remission in Crohn's disease.
However, corticosteroids can cause significant adverse events. Budesonide is an alternate …

We undertook a meta-analysis of six Crohn's disease genome-wide association studies (GWAS)
comprising 6,333 affected individuals (cases) and 15,056 controls and followed up the …

Several risk factors for Crohn's disease have been identified in recent genome-wide association
studies. To advance gene discovery further, we combined data from three studies on …

We present a genome-wide association study of ileal Crohn disease and two independent
replication studies that identify several new regions of association to Crohn disease. …

Deep vein thrombosis (DVT) is a major cause of cardiovascular death. The sequence of
events that promote DVT remains obscure, largely as a result of the lack of an appropriate …

Genome-wide association studies and candidate gene studies in ulcerative colitis have
identified 18 susceptibility loci. We conducted a meta-analysis of six ulcerative colitis genome-…

Background Although corticosteroids are highly effective in improving symptoms of Crohn's
disease, they may have substantial toxicity. In some patients, attempts to discontinue …

The chronic inflammatory bowel diseases (IBDs)—Crohn disease (CD) and ulcerative colitis
(UC)—are idiopathic, inflammatory disorders of the gastrointestinal tract. These conditions …