In less than 50 years the field of organ transplantation has transitioned from an experimental
concept to clinical commonplace. Notwithstanding the dramatic improvements in patient …

The myriad of co-stimulatory signals expressed, or induced, upon T-cell activation suggests
that these signalling pathways shape the character and magnitude of the resulting …

… protein B7/BB-1 or B7-1 (named after the Ab clones that were used to identify it but later
renamed as … Intriguingly, in several systems Ab therapy directed at CD80 alone was ineffective, …

Current success in organ transplantation is dependent upon the use of calcineurin-inhibitor-based
im-munosuppressive regimens. Unfortunately, current immunotherapy targets …

Many strategies have been proposed to induce tolerance to transplanted tissue in rodents;
however, few if any have shown equal efficacy when tested in nonhuman primate transplant …

Background: We previously demonstrated a markedly dependent distribution of ventilator-induced
lung injury in oleic acid-injured supine animals ventilated with large tidal volumes and …

To determine if decreased respiratory frequency (ventilatory rate) improves indices of lung
damage, 17 sets of isolated, perfused rabbit lungs were ventilated with a peak static airway …

Xenotransplantation has the potential to alleviate the organ shortage that prevents many
patients with end‐stage renal disease from enjoying the benefits of kidney transplantation. …

Recruitment maneuvers (RM), consisting of sustained inflations at high airway pressures,
have been advocated as an adjunct to mechanical ventilation in acute respiratory distress …

Transplantation tolerance, defined as allograft acceptance by an immunocompetent recipient
in the absence of long-term immunosuppression, has remained an elusive goal in clinical …