Characteristic patterns of variation over time, namely rhythms, represent a defining feature
of complex systems, one that is synonymous with life. Despite the intrinsic dynamic, …

… Seely and Christou) and Surgical Critical Care (Dr. Christou), Royal Victoria Hospital,
McGill University Health Center, Montreal, Canada. … Graham Barr, Alain Deschamps …

Abstract Analysis of patterns of variation of time-series, termed variability analysis, represents
a rapidly evolving discipline with increasing applications in different fields of science. In …

Background Studies that have evaluated the use of intravenous vitamin C in adults with
sepsis who were receiving vasopressor therapy in the intensive care unit (ICU) have shown …

BACKGROUND: Objective reporting of postoperative complications is the foundation of
surgical quality assurance. We developed a system to identify both presence and severity of …

… Seely reports that he founded and holds equity in Therapeutic Monitoring Systems and
has 2 patents issued to the company. Authors not named here have disclosed no conflicts of …

Background Early diagnosis of sepsis enables timely resuscitation and antibiotics and
prevents subsequent morbidity and mortality. Clinical approaches relying on point-in-time …

Background. Melatonin (MLT) is known to possess potent antioxidant, antiproliferative,
immune-modulating, and hormone-modulating properties. Clinical evidence suggests that MLT …

Objective: We sought to summarize accuracy of physical examination, imaging, and Laboratory
Risk Indicator for Necrotizing Fasciitis (LRINEC) score in diagnosis of necrotizing soft …

Purpose In shock, hypotension may contribute to inadequate oxygen delivery, organ failure
and death. We conducted the Optimal Vasopressor Titration (OVATION) pilot trial to inform …