Post-transplant lymphoproliferative disorders (PTLD) are a serious complication after solid
organ or allogeneic hematopoietic stem cell transplantation and include a range of diseases …

There is a rich knowledge of the enteric nervous system (ENS), especially the neurochemical
and neurophysiological properties of enteric neurons and how they communicate in neural …

Objective. —To determine ifN-acetyltransferase 2 (NAT2) polymorphisms result in decreased
capacity to detoxify carcinogenic aromatic amines in cigarette smoke, thus making some …

BACKGROUND & AIMS: The transient receptor potential (TRP) channel family includes
transducers of mechanical and chemical stimuli for visceral sensory neurons. TRP ankyrin 1 (…

Background & Aims Linaclotide is a minimally absorbed agonist of guanylate cyclase-C (GUCY2C
or GC-C) that reduces symptoms associated with irritable bowel syndrome with …

Inducible Ca2+-independent nitric oxide synthase (NOS), also referred to as NOS2, which is
expressed in a variety of human cancers (1–4), can generate mutagenic concentrations of …

Objective The gut is a major site of contact between immune and sensory systems and
evidence suggests that patients with irritable bowel syndrome (IBS) have immune dysfunction. …

Irritable bowel syndrome and inflammatory bowel disease are major forms of chronic visceral
pain, which affect over 15% of the global population. In order to identify new therapies, it is …

Transient receptor potential ion channel melastatin subtype 8 (TRPM8) is activated by cold
temperatures and cooling agents, such as menthol and icilin. Compounds containing …

Non‐technical summary Detecting mechanical stimuli is vital to determining our responses
to environmental challenges. The speed required for this process suggests ion channels are …