Background Patients with incomplete surgical resection of medulloblastoma are controversially
regarded as having a marker of high-risk disease, which leads to patients undergoing …

Lys-27-Met mutations in histone 3 genes (H3K27M) characterize a subgroup of deadly gliomas
and decrease genome-wide H3K27 trimethylation. Here we use primary H3K27M tumor …

Canonical (H3.1/H3.2) and noncanonical (H3.3) histone 3 K27M-mutant gliomas have unique
spatiotemporal distributions, partner alterations and molecular profiles. The contribution of …

Childhood brain tumors have suspected prenatal origins. To identify vulnerable developmental
states, we generated a single-cell transcriptome atlas of >65,000 cells from embryonal …

High-grade gliomas defined by histone 3 K27M driver mutations exhibit global loss of H3K27
trimethylation and reciprocal gain of H3K27 acetylation, respectively shaping repressive …

Histone H3.3 glycine 34 to arginine/valine (G34R/V) mutations drive deadly gliomas and
show exquisite regional and temporal specificity, suggesting a developmental context …

Objective To report the feasibility, safety, and clinical outcomes of an exploratory study of
MR ‐guided Laser Interstitial Thermal Therapy ( MR g LITT ) as a minimally invasive surgical …

Patients with temporal lobe epilepsy (TLE) are refractory to antiepileptic drugs in about 30%
of cases. Surgical treatment has been shown to be beneficial for the selected patients but …

Object Resection of spinal tumors traditionally requires bilateral subperiosteal muscle
stripping, extensive laminectomy, and, in cases of foraminal extension, partial or radical …

Objective To evaluate the quality of information available on the Internet to patients with a
cervical pathology undergoing elective cervical spine surgery. Methods Six key words (“…