[HTML][HTML] Flattening the COVID-19 curve with natural killer cell based immunotherapies

M Market, L Angka, AB Martel, D Bastin… - Frontiers in …, 2020 - frontiersin.org
Natural Killer (NK) cells are innate immune responders critical for viral clearance and
immunomodulation. Despite their vital role in viral infection, the contribution of NK cells in fighting …

[HTML][HTML] Natural killer cell IFNγ secretion is profoundly suppressed following colorectal cancer surgery

L Angka, AB Martel, M Kilgour, A Jeong… - Annals of Surgical …, 2018 - Springer
Background Surgical stress results in a significant reduction in natural killer (NK) cell
cytotoxicity (NKC), which has been linked to postoperative cancer metastases. However, few …

[HTML][HTML] Safety and efficacy of autologous cell vaccines in solid tumors: a systematic review and meta-analysis of randomized control trials

…, AB Martel, R Shorr, M Ghiasi, DM Boucher, B Wong… - Scientific reports, 2023 - nature.com
We conducted a systematic review and meta-analysis of randomized control trials to formally
assess the safety and efficacy of autologous whole cell vaccines as immunotherapies for …

Gender and academic promotion of Canadian general surgeons: a cross-sectional study

N Gawad, A Tran, AB Martel, NN Baxter… - … Open Access Journal, 2020 - cmajopen.ca
Background: Gender disparities in faculty rank have yet to be studied among Canadian
physicians. The purpose of this study was to determine whether differences in region, training, …

[HTML][HTML] Prognostic significance of a positive radial margin after esophageal cancer resection

S Gilbert, AB Martel, AJ Seely, DE Maziak… - The Journal of Thoracic …, 2015 - Elsevier
Objective The prognostic significance of an incomplete esophageal cancer resection due to
a positive microscopic radial margin remains unclear. The aim of this study is to examine the …

[HTML][HTML] Perioperative arginine prevents metastases by accelerating natural killer cell recovery after surgery

…, KE Baxter, ST Khan, M Market, AB Martel… - Molecular Therapy, 2022 - cell.com
Profound natural killer (NK) cell suppression after cancer surgery is a main driver of metastases
and recurrence, for which there is no clinically approved intervention available. Surgical …

A translational randomized trial of perioperative arginine immunonutrition on natural killer cell function in colorectal cancer surgery patients

L Angka, AB Martel, J Ng, A Pecarskie, M Sadiq… - Annals of Surgical …, 2022 - Springer
Background Surgery results in severe impairment of natural killer (NK) cell cytotoxicity (NKC)
and activity (NKA, cytokine secretion), and a dramatic drop in arginine levels. Postoperative …

Safety and efficacy of autologous whole cell vaccines in hematologic malignancies: A systematic review and meta‐analysis

…, MA Kennedy, N Forbes, AB Martel… - Hematological …, 2021 - Wiley Online Library
Autologous cell vaccines use a patient's tumor cells to stimulate a broad antitumor response
in vivo. This approach shows promise for treating hematologic cancers in early phase …

A Systematic Review of Evidence Supporting the Use of Autologous Cell Vaccines in the Treatment of Hematological Malignancies

…, AB Martel, L Baker, L Gresham, D Boucher, B Wong… - Blood, 2020 - Elsevier
By presenting a patient's own tumor antigens to their immune system, autologous cancer
cell vaccines can drive a robust polyclonal adaptive response. In this systematic review and …

ASO Visual Abstract: A Translational Randomized Trial of Perioperative Arginine Immunonutrition on Natural Killer Cell Function in Colorectal Cancer Surgery Patients

L Angka, AB Martel, J Ng, A Pecarskie… - Annals of Surgical …, 2022 - search.proquest.com
… ASO VISUAL ABSTRACT ASO Visual Abstract: A Translational Randomized Trial of
Perioperative Arginine Immunonutrition on Natural Killer Cell Function in Colorectal Cancer …