[HTML][HTML] Advances in stem cell therapy for spinal cord injury
AJ Mothe, CH Tator - The Journal of clinical investigation, 2012 - Am Soc Clin Investig
Spinal cord injury (SCI) is a devastating condition producing great personal and societal
costs and for which there is no effective treatment. Stem cell transplantation is a promising …
costs and for which there is no effective treatment. Stem cell transplantation is a promising …
Repair of the injured spinal cord by transplantation of neural stem cells in a hyaluronan-based hydrogel
AJ Mothe, RY Tam, T Zahir, CH Tator, MS Shoichet - Biomaterials, 2013 - Elsevier
Traumatic injury to the spinal cord causes cell death, demyelination, axonal degeneration,
and cavitation resulting in functional motor and sensory loss. Stem cell therapy is a promising …
and cavitation resulting in functional motor and sensory loss. Stem cell therapy is a promising …
Review of transplantation of neural stem/progenitor cells for spinal cord injury
AJ Mothe, CH Tator - International Journal of Developmental Neuroscience, 2013 - Elsevier
Spinal cord injury (SCI) is a debilitating condition often resulting in paralysis, yet currently
there is no effective treatment. Stem cell transplantation is a promising therapeutic strategy for …
there is no effective treatment. Stem cell transplantation is a promising therapeutic strategy for …
An in vivo characterization of trophic factor production following neural precursor cell or bone marrow stromal cell transplantation for spinal cord injury
GWJ Hawryluk, A Mothe, J Wang, S Wang… - Stem cells and …, 2012 - liebertpub.com
Cellular transplantation strategies for repairing the injured spinal cord have shown consistent
benefit in preclinical models, and human clinical trials have begun. Interactions between …
benefit in preclinical models, and human clinical trials have begun. Interactions between …
The leading edge: Emerging neuroprotective and neuroregenerative cell-based therapies for spinal cord injury
CS Ahuja, A Mothe, M Khazaei… - Stem cells …, 2020 - academic.oup.com
Spinal cord injuries (SCIs) are associated with tremendous physical, social, and financial
costs for millions of individuals and families worldwide. Rapid delivery of specialized medical …
costs for millions of individuals and families worldwide. Rapid delivery of specialized medical …
Large animal and primate models of spinal cord injury for the testing of novel therapies
Large animal and primate models of spinal cord injury (SCI) are being increasingly utilized
for the testing of novel therapies. While these represent intermediary animal species between …
for the testing of novel therapies. While these represent intermediary animal species between …
[HTML][HTML] Neural stem/progenitor cells from the adult human spinal cord are multipotent and self-renewing and differentiate after transplantation
AJ Mothe, T Zahir, C Santaguida, D Cook, CH Tator - PloS one, 2011 - journals.plos.org
Neural stem/progenitor cell (NSPC) transplantation is a promising therapy for spinal cord
injury (SCI). However, little is known about NSPC from the adult human spinal cord as a donor …
injury (SCI). However, little is known about NSPC from the adult human spinal cord as a donor …
Transplanted neural stem/progenitor cells generate myelinating oligodendrocytes and Schwann cells in spinal cord demyelination and dysmyelination
AJ Mothe, CH Tator - Experimental neurology, 2008 - Elsevier
Stem cell therapy is a promising approach for remyelination strategies in demyelinating and
traumatic disorders of the spinal cord. Self-renewing neural stem/progenitor cells (NSPCs) …
traumatic disorders of the spinal cord. Self-renewing neural stem/progenitor cells (NSPCs) …
Characterization of hyaluronan–methylcellulose hydrogels for cell delivery to the injured spinal cord
MJ Caicco, T Zahir, AJ Mothe, BG Ballios… - … research Part A, 2013 - Wiley Online Library
No effective clinical treatment currently exists for traumatic spinal cord injury. Cell replacement
therapy holds promise for attaining functional repair. Cells may be delivered directly or …
therapy holds promise for attaining functional repair. Cells may be delivered directly or …
[HTML][HTML] RGMa inhibition with human monoclonal antibodies promotes regeneration, plasticity and repair, and attenuates neuropathic pain after spinal cord injury
Traumatic spinal cord injury (SCI) causes a cascade of degenerative events including cell
death, axonal damage, and the upregulation of inhibitory molecules which prevent …
death, axonal damage, and the upregulation of inhibitory molecules which prevent …