[HTML][HTML] Advances in stem cell therapy for spinal cord injury

AJ Mothe, CH Tator - The Journal of clinical investigation, 2012 - Am Soc Clin Investig
Spinal cord injury (SCI) is a devastating condition producing great personal and societal
costs and for which there is no effective treatment. Stem cell transplantation is a promising …

Repair of the injured spinal cord by transplantation of neural stem cells in a hyaluronan-based hydrogel

AJ Mothe, RY Tam, T Zahir, CH Tator, MS Shoichet - Biomaterials, 2013 - Elsevier
Traumatic injury to the spinal cord causes cell death, demyelination, axonal degeneration,
and cavitation resulting in functional motor and sensory loss. Stem cell therapy is a promising …

Review of transplantation of neural stem/progenitor cells for spinal cord injury

AJ Mothe, CH Tator - International Journal of Developmental Neuroscience, 2013 - Elsevier
Spinal cord injury (SCI) is a debilitating condition often resulting in paralysis, yet currently
there is no effective treatment. Stem cell transplantation is a promising therapeutic strategy for …

An in vivo characterization of trophic factor production following neural precursor cell or bone marrow stromal cell transplantation for spinal cord injury

GWJ Hawryluk, A Mothe, J Wang, S Wang… - Stem cells and …, 2012 - liebertpub.com
Cellular transplantation strategies for repairing the injured spinal cord have shown consistent
benefit in preclinical models, and human clinical trials have begun. Interactions between …

The leading edge: Emerging neuroprotective and neuroregenerative cell-based therapies for spinal cord injury

CS Ahuja, A Mothe, M Khazaei… - Stem cells …, 2020 - academic.oup.com
Spinal cord injuries (SCIs) are associated with tremendous physical, social, and financial
costs for millions of individuals and families worldwide. Rapid delivery of specialized medical …

Large animal and primate models of spinal cord injury for the testing of novel therapies

…, DSK Magnuson, M Marsala, SW Moore, AJ Mothe… - Experimental …, 2015 - Elsevier
Large animal and primate models of spinal cord injury (SCI) are being increasingly utilized
for the testing of novel therapies. While these represent intermediary animal species between …

[HTML][HTML] Neural stem/progenitor cells from the adult human spinal cord are multipotent and self-renewing and differentiate after transplantation

AJ Mothe, T Zahir, C Santaguida, D Cook, CH Tator - PloS one, 2011 - journals.plos.org
Neural stem/progenitor cell (NSPC) transplantation is a promising therapy for spinal cord
injury (SCI). However, little is known about NSPC from the adult human spinal cord as a donor …

Transplanted neural stem/progenitor cells generate myelinating oligodendrocytes and Schwann cells in spinal cord demyelination and dysmyelination

AJ Mothe, CH Tator - Experimental neurology, 2008 - Elsevier
Stem cell therapy is a promising approach for remyelination strategies in demyelinating and
traumatic disorders of the spinal cord. Self-renewing neural stem/progenitor cells (NSPCs) …

Characterization of hyaluronan–methylcellulose hydrogels for cell delivery to the injured spinal cord

MJ Caicco, T Zahir, AJ Mothe, BG Ballios… - … research Part A, 2013 - Wiley Online Library
No effective clinical treatment currently exists for traumatic spinal cord injury. Cell replacement
therapy holds promise for attaining functional repair. Cells may be delivered directly or …

[HTML][HTML] RGMa inhibition with human monoclonal antibodies promotes regeneration, plasticity and repair, and attenuates neuropathic pain after spinal cord injury

AJ Mothe, NG Tassew, AP Shabanzadeh, R Penheiro… - Scientific reports, 2017 - nature.com
Traumatic spinal cord injury (SCI) causes a cascade of degenerative events including cell
death, axonal damage, and the upregulation of inhibitory molecules which prevent …