Objective: To provide a uniform platform from which to study acute liver failure, the US Acute
Liver Failure Study Group has sought to standardize the management of patients with acute …

Objectives: To summarize randomized controlled trials on the effects of sedative agents on
neurologic outcome, mortality, intracranial pressure, cerebral perfusion pressure, and …

Introduction Anemia is one of the most common medical complications to be encountered in
critically ill patients. Based on the results of clinical trials, transfusion practices across the …

Introduction Hyper- and hypoglycemia are strongly associated with adverse outcomes in
critical care. Neurologically injured patients are a unique subgroup, where optimal glycemic …

Importance Brain injury biomarkers released into circulation from the injured neurovascular
unit are important prognostic tools in patients with cardiac arrest who develop hypoxic …

Objective: Patients with subarachnoid hemorrhage (SAH) frequently develop delayed
cerebral ischemia and may be especially vulnerable to the effects of anemia. However, the …

This 2023 Clinical Practice Guideline provides the biomedical definition of death based on
permanent cessation of brain function that applies to all persons, as well as …

Object Delayed cerebral ischemia is a major cause of morbidity and death following aneurysmal
subarachnoid hemorrhage and requires timely intervention for a successful outcome to …

A variety of organizational models have been used to deliver care to critically ill patients with
neurologic disorders. Primary care may be provided by general intensivists, who often rely …

Background The minimum duration of pulselessness required before organ donation after
circulatory determination of death has not been well studied. Methods We conducted a …