User profiles for Andrew Giles

Andrew C Giles

- Verified email at unbc.ca - Cited by 1380

Andrew E. Giles

- Verified email at kingstonhsc.ca - Cited by 174

High-throughput behavioral analysis in C. elegans

NA Swierczek, AC Giles, CH Rankin, RA Kerr - Nature methods, 2011 - nature.com
We designed a real-time computer vision system, the Multi-Worm Tracker (MWT), which can
simultaneously quantify the behavior of dozens of Caenorhabditis elegans on a Petri plate …

Young children's theory of mind and emotion

PL Harris, CN Johnson, D Hutton, G Andrews… - Cognition & …, 1989 - Taylor & Francis
In three experiments, children aged 3 to 7 years were tested for their understanding of the
impact of beliefs and desires on emotion. Children watched while animal characters were …

[PDF][PDF] Dopamine mediates context-dependent modulation of sensory plasticity in C. elegans

KS Kindt, KB Quast, AC Giles, S De, D Hendrey… - Neuron, 2007 - cell.com
Dopamine has been implicated in the modulation of diverse forms of behavioral plasticity,
including appetitive learning and addiction. An important challenge is to understand how …

The use of a temporal analogue to investigate the possible impact of projected global warming on the UK tourist industry

AR Giles, AH Perry - Tourism management, 1998 - Elsevier
Tourism in the UK benefited from the continued ‘hot spell’ throughout the three summer
months in 1995. A revival of the traditional British seaside holiday was experienced whilst …

Behavioral and genetic characterization of habituation using Caenorhabditis elegans

AC Giles, CH Rankin - Neurobiology of learning and memory, 2009 - Elsevier
This review surveys the literature that investigates the behavioral characterization and
cellular and molecular mechanisms of habituation using the model organism Caenorhabditis …

Effect of colchicine on perioperative atrial fibrillation and myocardial injury after non-cardiac surgery in patients undergoing major thoracic surgery (COP-AF): an …

…, M Karizhenskaia, A Malik, R Tanzola, A Giles… - The Lancet, 2023 - thelancet.com
Background Higher levels of inflammatory biomarkers are associated with an increased risk
of perioperative atrial fibrillation and myocardial injury after non-cardiac surgery (MINS). …

Ptchd1 mediates opioid tolerance via cholesterol-dependent effects on μ-opioid receptor trafficking

…, HM Stoveken, M Dao, OK Sial, AC Giles… - Nature …, 2022 - nature.com
Repeated exposure to opioids causes tolerance, which limits their analgesic utility and
contributes to overdose and abuse liability. However, the molecular mechanisms underpinning …

Genetic behavioral screen identifies an orphan anti-opioid system

…, I Masuho, C Johnston, KJ Opperman, AC Giles… - Science, 2019 - science.org
Opioids target the μ-opioid receptor (MOR) to produce unrivaled pain management, but their
addictive properties can lead to severe abuse. We developed a whole-animal behavioral …

Genetic modeling of GNAO1 disorder delineates mechanisms of Gαo dysfunction

D Wang, M Dao, BS Muntean, AC Giles… - Human Molecular …, 2022 - academic.oup.com
GNAO1 encephalopathy is a neurodevelopmental disorder with a spectrum of symptoms that
include dystonic movements, seizures and developmental delay. While numerous GNAO1 …

Context-dependent operation of neural circuits underlies a navigation behavior in Caenorhabditis elegans

M Ikeda, S Nakano, AC Giles, L Xu… - Proceedings of the …, 2020 - National Acad Sciences
The nervous system evaluates environmental cues and adjusts motor output to ensure
navigation toward a preferred environment. The nematode Caenorhabditis elegans navigates in …