Characterizing white matter damage in rat spinal cord with quantitative MRI and histology

P Kozlowski, D Raj, JIE Liu, C Lam, AC Yung… - Journal of …, 2008 - liebertpub.com
Diffusion tensor imaging (DTI) and quantitative T 2 magnetic resonance imaging (MRI) were
used to characterize ex vivo the white matter damage at 3 and 8 weeks following dorsal …

Brainstem spreading depolarization and cortical dynamics during fatal seizures in Cacna1a S218L mice

…, SM Cain, M Schenke, RA Voskuyl, AC Yung… - Brain, 2019 - academic.oup.com
Sudden unexpected death in epilepsy (SUDEP) is a fatal complication of epilepsy in which
brainstem spreading depolarization may play a pivotal role, as suggested by animal studies. …

Effect of acetabular labral tears, repair and resection on hip cartilage strain: a 7 T MR study

LL Greaves, MK Gilbart, AC Yung, P Kozlowski… - Journal of …, 2010 - Elsevier
BACKGROUND: Tears of the acetabular labrum are frequently present in patients with groin
pain. While it is clear that the labrum contributes to the surface area articulating with the …

Development and evaluation of a dual-modality (MRI/SPECT) molecular imaging bioprobe

R Misri, D Meier, AC Yung, P Kozlowski… - … , Biology and Medicine, 2012 - Elsevier
Specific bioprobes for single photon emission computed tomography (SPECT) and magnetic
resonance imaging (MRI) have enormous potential for use in cancer imaging in near-future …

High‐resolution myelin water measurements in rat spinal cord

P Kozlowski, J Liu, AC Yung… - Magnetic Resonance in …, 2008 - Wiley Online Library
Multiecho imaging data were acquired at 7T from control and injured (dorsal column
transection) rat spinal cords ex vivo with in‐plane resolution of 61, 78, and 100 μm, and from a …

In vivo imaging reveals that pregabalin inhibits cortical spreading depression and propagation to subcortical brain structures

…, B Bohnet, J LeDue, AC Yung… - Proceedings of the …, 2017 - National Acad Sciences
Migraine is characterized by severe headaches that can be preceded by an aura likely
caused by cortical spreading depression (SD). The antiepileptic pregabalin (Lyrica) shows …

Transient hypertension after spinal cord injury leads to cerebrovascular endothelial dysfunction and fibrosis

…, A Monga, MMZ Zheng, R Sachdeva, A Yung… - Journal of …, 2018 - liebertpub.com
We aimed to create a clinically relevant pre-clinical model of transient hypertension, and
then evaluate the pathophysiological cerebrovascular processes resulting from this novel …

Irinophore C, a novel nanoformulation of irinotecan, alters tumor vascular function and enhances the distribution of 5-fluorouracil and doxorubicin

…, M Anantha, TJ Ruth, MJ Adam, A Yung… - Clinical Cancer …, 2008 - AACR
Purpose: To examine the antitumor effects of Irinophore C, a nanopharmaceutical formulation
of irinotecan, on the tissue morphology and function of tumor vasculature in HT-29 human …

[HTML][HTML] Vascular normalization in orthotopic glioblastoma following intravenous treatment with lipid-based nanoparticulate formulations of irinotecan (Irinophore C™) …

M Verreault, D Strutt, D Masin, M Anantha, A Yung… - BMC cancer, 2011 - Springer
Background Chemotherapy for glioblastoma (GBM) patients is compromised in part by poor
perfusion in the tumor. The present study evaluates how treatment with liposomal …

AAV5-miHTT-mediated huntingtin lowering improves brain health in a Huntington's disease mouse model

…, M Vermeulen, S Mostafavi, TL Petkau, A Hill, A Yung… - Brain, 2023 - academic.oup.com
Huntingtin (HTT)-lowering therapies show great promise in treating Huntington’s disease.
We have developed a microRNA targeting human HTT that is delivered in an adeno-…