… Dr O’Brien is supported by a career award in Health Sciences from the Health Research
Foundation of the Prescription Drug Manufacturers Association and the Medical Research …

▪ Abstract As many more clinical trials collect economic information within their study design,
so health economics analysts are increasingly working with patient-level data on both costs …

Most human phenotypes are influenced by a combination of genomic and environmental
factors. Engaging in regular physical exercise prevents many chronic diseases, decreases …

Glioblastoma is the most common primary malignant brain tumor in adults and is associated
with poor survival. The Ivy Foundation Early Phase Clinical Trials Consortium conducted a …

… O’Brien BJ, Briggs AH. Analysis of uncertainty in health care cost-effectiveness studies:
an introduction to statistical issues and methods. Stat Methods Med Res 2002; 11: 455–468. …

ContextAlthough advance directives are commonly used in the community, little is known
about the effects of their systematic implementation.ObjectivesTo examine the effect of …

Background Every year in Ontario, the records of over 42 million prescriptions dispensed to
persons eligible for Ontario Drug Benefit (ODB) benefits are transmitted to a central database…

… For example, O'Brien et a115 used ?2 standard deviations around the sample mean for
time taken by doctors to re-site infusions as a sensitivity variant in their study of the infusion …

When choosing between mutually exclusive treatment options, it is common to construct a
cost-effectiveness frontier on the cost-effectiveness plane that represents efficient points from …

Background The primary aim of this study was to compare quality-of-life outcome between
patients randomized to implantable cardioverter defibrillator (ICD) therapy and patients …