User profiles for Bryan J Heard
 | Bryan J. HeardUniversity of Calgary, Faculty of Medicine Verified email at ucalgary.ca Cited by 945 |
Use of pre‐clinical surgically induced models to understand biomechanical and biological consequences of PTOA development
Post‐traumatic osteoarthritis (PTOA) development is often observed following traumatic knee
injuries involving key stabilising structures such as the cruciate ligaments or the menisci. …
injuries involving key stabilising structures such as the cruciate ligaments or the menisci. …
Single intra‐articular dexamethasone injection immediately post‐surgery in a rabbit model mitigates early inflammatory responses and post‐traumatic osteoarthritis …
Despite surgical reconstruction of the anterior cruciate ligament, a significant number of
patients will still develop post‐traumatic osteoarthritis (PTOA). Our objective was to determine if …
patients will still develop post‐traumatic osteoarthritis (PTOA). Our objective was to determine if …
Metabolic profiling of synovial fluid in a unilateral ovine model of anterior cruciate ligament reconstruction of the knee suggests biomarkers for early osteoarthritis
B Mickiewicz, BJ Heard, JK Chau… - Journal of …, 2015 - Wiley Online Library
Joint injuries and subsequent osteoarthritis (OA) are the leading causes of chronic joint
disease. In this work, we explore the possibility of applying magnetic resonance spectroscopy‐…
disease. In this work, we explore the possibility of applying magnetic resonance spectroscopy‐…
[HTML][HTML] Matrix metalloproteinase protein expression profiles cannot distinguish between normal and early osteoarthritic synovial fluid
BJ Heard, L Martin, JB Rattner, CB Frank… - BMC musculoskeletal …, 2012 - Springer
Background Osteoarthritis (OA) and Rheumatoid arthritis (RA) are diseases which result in
the degeneration of the joint surface articular cartilage. Matrix Metalloproteinases (MMPs) are …
the degeneration of the joint surface articular cartilage. Matrix Metalloproteinases (MMPs) are …
Monocyte chemotactic protein-1 inhibits chondrogenesis of synovial mesenchymal progenitor cells: an in vitro study
Osteoarthritis (OA) is a multifactorial, often progressive, painful disease. OA often progresses
with an apparent irreversible loss of articular cartilage, exposing underlying bone, resulting …
with an apparent irreversible loss of articular cartilage, exposing underlying bone, resulting …
A computational method to differentiate normal individuals, osteoarthritis and rheumatoid arthritis patients using serum biomarkers
BJ Heard, JM Rosvold, MJ Fritzler… - Journal of The …, 2014 - royalsocietypublishing.org
The objective of this study was to develop a method for categorizing normal individuals (normal,
n = 100) as well as patients with osteoarthritis (OA, n = 100), and rheumatoid arthritis (RA…
n = 100) as well as patients with osteoarthritis (OA, n = 100), and rheumatoid arthritis (RA…
Intraarticular and systemic inflammatory profiles may identify patients with osteoarthritis
BJ Heard, MJ Fritzler, JP Wiley, J McAllister… - The Journal of …, 2013 - jrheum.org
Objective. To determine whether cytokine/chemokine profiles from synovial fluid and sera
discriminate mild/moderate osteoarthritis (OA) from normal and severe OA cohorts. Methods. …
discriminate mild/moderate osteoarthritis (OA) from normal and severe OA cohorts. Methods. …
Complete ACL/MCL deficiency induces variable degrees of instability in sheep with specific kinematic abnormalities correlating with degrees of early osteoarthritis
…, JE Beveridge, KD Huebner, BJ Heard… - Journal of …, 2012 - Wiley Online Library
People are not equally disabled by combined anterior cruciate ligament (ACL)/medial collateral
ligament (MCL) injuries, nor do they all develop osteoarthritis (OA). Although biological/…
ligament (MCL) injuries, nor do they all develop osteoarthritis (OA). Although biological/…
Early joint tissue changes are highly correlated with a set of inflammatory and degradative synovial biomarkers after ACL autograft and its sham surgery in an ovine …
BJ Heard, Y Achari, M Chung… - Journal of …, 2011 - Wiley Online Library
While impossible in humans, the mechanisms of early cartilage, bone and meniscal damage
can be quantified after anterior cruciate ligament (ACL) injury in animal models. We utilized …
can be quantified after anterior cruciate ligament (ACL) injury in animal models. We utilized …
Investigating the potential value of individual parameters of histological grading systems in a sheep model of cartilage damage: the Modified Mankin method
HR Moody, BJ Heard, CB Frank, NG Shrive… - Journal of …, 2012 - Wiley Online Library
A total histological grade does not necessarily distinguish between different manifestations
of cartilage damage or degeneration. An accurate and reliable histological assessment …
of cartilage damage or degeneration. An accurate and reliable histological assessment …