Glioma is the most common primary cancer of the central nervous system, and around 50%
of patients present with the most aggressive form of the disease, glioblastoma. Conventional …

Several current immunotherapy approaches target private neoantigens derived from mutations
that are unique to individual patients’ tumors. However, immunotherapeutic agents can …

… https://orcid.org/0000-0002-7567-5542, Chetan Bettegowda … Pantel, C. Alix-Panabières,
Liquid biopsy and minimal residual disease—Latest advances and implications for cure. Nat …

The development of noninvasive methods to detect and monitor tumors continues to be a
major challenge in oncology. We used digital polymerase chain reaction–based technologies …

… We are grateful to C. Blair and K. Judge for expert technical and administrative assistance. …
We are grateful to C. Blair and K. Judge for expert technical and administrative assistance. …

Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer
worldwide. To explore the genetic origins of this cancer, we used whole-exome sequencing and …

Malignant cells, like all actively growing cells, must maintain their telomeres, but genetic
mechanisms responsible for telomere maintenance in tumors have only recently been …

The proteins encoded by ATRX and DAXX participate in chromatin remodeling at telomeres
and other genomic sites. Because inactivating mutations of these genes are common in …

Medulloblastoma (MB) is the most common malignant brain tumor of children. To identify the
genetic alterations in this tumor type, we searched for copy number alterations using high-…

Mutations in the critical chromatin modifier ATRX and mutations in CIC and FUBP1, which are
potent regulators of cell growth, have been discovered in specific subtypes of gliomas, the …