Background Pancreaticoduodenectomy is the primary treatment for periampullary cancer.
Associated morbidity is high and often related to pancreatic anastomotic failure. This paper …

… CS indicates the positive feelings associated with doing a type of work, and a higher
score is suggestive of more contentment. Higher scores in STS and BO would indicate more …

Introduction Administrative health data have been used to study sepsis in large population-based
studies. The validity of these study findings depends largely on the quality of the …

It has been known for many years that neutrophils and platelets participate in the pathogenesis
of severe sepsis, but the inter-relationship between these players is completely unknown. …

Context The expression and release of tissue factor is a major trigger for the activation of
coagulation in patients with sepsis. Tissue factor pathway inhibitor (TFPI) forms a complex with …

Background Some observational studies suggest that the use of pulmonary-artery catheters
to guide therapy is associated with increased mortality. Methods We performed a …

Introduction Severe acute renal failure (sARF) is associated with considerable morbidity,
mortality and use of healthcare resources; however, its precise epidemiology and long-term …

We conducted a prospective, observational cohort study designed to compare intestinal
permeability (IP) and development of multiple organ dysfunction syndrome (MODS) in a subset …

Objective: To evaluate whether administration of afelimomab, an anti-tumor necrosis factor F
(ab′) 2 monoclonal antibody fragment, would reduce 28-day all-cause mortality in patients …

Importance Growing interest in microbial dysbiosis during critical illness has raised
questions about the therapeutic potential of microbiome modification with probiotics. Prior …