Background Autoimmune and autoinflammatory diseases involve interactions between genetic
risk factors and environmental triggers. We searched for a gene on chromosome 17p13 …

Background Generalized vitiligo is an autoimmune disease characterized by melanocyte
loss, which results in patchy depigmentation of skin and hair, and is associated with an …

Generalized vitiligo is an autoimmune disorder in which acquired white patches of skin and
overlying hair result from autoimmune loss of melanocytes from involved areas. Although …

Nuclear localization leucine-rich-repeat protein 1 (NLRP1) is a key regulator of the innate
immune system, particularly in the skin where, in response to molecular triggers such as …

Objective Guidelines recommend exercise as a core treatment for knee osteoarthritis. However,
it is unclear how exercise affects measures of pain processing and motor function. The …

… (C and D) Gli1 mRNA was detected by in situ hybridization in the Purkinje (arrows) and
granule (arrowheads) cells of control embryos (C) but was largely missing in Lhx1/Lhx5 double-…

In a recent genome-wide association study of generalized vitiligo, we identified ten confirmed
susceptibility loci. By testing additional loci that showed suggestive association in the …

… condition was measured as the difference between the C T value for the specific region
relative to the geometric mean of the C T values for three control regions not predicted to occupy …

Glucocorticoids (GCs), which activate GC receptor (GR) signaling and thus modulate gene
expression, are widely used to treat asthma. GCs exert their therapeutic effects in part through …

Objective To determine the absolute and relative intra-rater within-session test-retest reliability
of pressure pain threshold (PPT) and mechanical temporal summation of pain (TSP) at …