[HTML][HTML] Sequential interchange of four amino acids from blood group B to blood group A glycosyltransferase boosts catalytic activity and progressively modifies …

NOL Seto, MM Palcic, CA Compston, H Li… - Journal of Biological …, 1997 - ASBMB
The human blood group A and B glycosyltransferase enzymes are highly homologous and
the alteration of four critical amino acid residues (Arg-176 → Gly, Gly-235 → Ser, Leu-266 → …

Accelerated senescence in kidneys of low-birth-weight rats after catch-up growth

VA Luyckx, CA Compston… - American Journal of …, 2009 - journals.physiology.org
Epidemiological studies show a strong association between low birth weight and hypertension,
renal, and cardiovascular disease, especially after catch-up growth. Senescence is an …

Donor substrate specificity of recombinant human blood group A, B and hybrid A/B glycosyltransferases expressed in Escherichia coli

NOL Seto, CA Compston, SV Evans… - European journal of …, 1999 - Wiley Online Library
… scintillation cocktail (ICN , St Laurent, Canada), and Centriplus-10 protein concentrators (…
Protein concentrations were determined using the BioRad (Hercules, CA, USA) microassay …

Oncostatin M pathway plays a major role in the renal acute phase response

VA Luyckx, LV Cairo, CA Compston… - American Journal …, 2009 - journals.physiology.org
The acute phase response is traditionally characterized by hepatic synthesis of proteins as
an inflammatory response to injury, with interleukin-6 (IL-6) being the key mediator. In contrast…

Enzymatic synthesis of blood group A and B trisaccharide analogues

NOL Seto, CA Compston, A Szpacenko… - Carbohydrate …, 2000 - Elsevier
Glycosyltransferases A and B utilize the donor substrates UDP-GalNAc and UDP-Gal,
respectively, in the biosynthesis of the human blood group A and B trisaccharide antigens from the …

Monitoring biosynthetic transformations of N-acetyllactosamine using fluorescently labeled oligosaccharides and capillary electrophoretic separation

YN Zhang, XC Le, NJ Dovichi, CA Compston… - Analytical …, 1995 - Elsevier
Capillary electrophoresis with laser-induced fluorescence detection was used to monitor
biosynthetic transformations of a labeled derivative of N-acetyllactosamine (β Gal(1 → 4)…

Use of restriction fragment length polymorphisms resolved by pulsed-field gel electrophoresis for subspecies identification of mycobacteria in the Mycobacterium …

JW Coffin, C Condon, CA Compston… - Journal of clinical …, 1992 - Am Soc Microbiol
Mycobacterial strains from the Mycobacterium avium complex were compared with each
other and with Mycobacterium phlei isolates by restriction endonuclease digestion of …

Study of the enzymatic transformation of fluorescently labeled oligosaccharides in human epidermoid cells using capillary electrophoresis with laser-induced …

XC Le, Y Zhang, NJ Dovichi, CA Compston… - … of Chromatography A, 1997 - Elsevier
Isomeric oligosaccharides of both βGal(1→3)βGlcNAc (type I) series and βGal(1→4)βGlcNAc
(type II) series were studied by using capillary electrophoresis (CE) with laser-induced …

Synthesis of the acceptor analog αFuc (1→ 2) αGal-O (CH2) 7 CH3: A probe for the kinetic mechanism of recombinant human blood group B glycosyltransferase

VP Kamath, NOL Seto, CA Compston… - Glycoconjugate …, 1999 - Springer
We report the chemical synthesis of αFuc(1→2)αGal-O(CH 2 ) 7 CH 3 (1) an analog of the
natural blood group (O)H disaccharide αFuc(1→2)βGal-OR. Compound 1 was a good …

The effect of hypoxia-induced intrauterine growth restriction on renal artery function

…, CF Rueda-Clausen, CA Compston… - … Origins of Health and …, 2012 - cambridge.org
… Centre, University of Alberta, Edmonton, Alberta T6G 2S2, Canada. (Email sandra.davidge@ualberta.ca)
a These authors have contributed equally to the preparation of this manuscript. …