User profiles for C.A. Giacomantonio
Carman GiacomantonioProfessor of Surgery, Dalhousie University Verified email at dal.ca Cited by 3278 |
Aldehyde dehydrogenase: its role as a cancer stem cell marker comes down to the specific isoform
P Marcato, CA Dean, CA Giacomantonio, PWK Lee - Cell cycle, 2011 - Taylor & Francis
Recent evidence suggests that enhanced aldehyde dehydrogenase (ALDH) activity is a
hallmark of cancer stem cells (CSC) measurable by the aldefluor assay. ALDH1A1, one of 19 …
hallmark of cancer stem cells (CSC) measurable by the aldefluor assay. ALDH1A1, one of 19 …
Aldehyde dehydrogenase activity of breast cancer stem cells is primarily due to isoform ALDH1A3 and its expression is predictive of metastasis
…, L Pan, A Leidal, S Gujar, CA Giacomantonio… - Stem …, 2011 - academic.oup.com
… As such, total isolated cell populations were frozen in Trizol RNA isolation solution (Invitrogen,
Burlington, Canada) and samples sent to Miltenyi biotech (Auburn, CA) for one-color …
Burlington, Canada) and samples sent to Miltenyi biotech (Auburn, CA) for one-color …
[HTML][HTML] Mast cells and skin and breast cancers: a complicated and microenvironment-dependent role
MR Hanes, CA Giacomantonio, JS Marshall - Cells, 2021 - mdpi.com
Mast cells are important sentinel cells in host defense against infection and major effector
cells in allergic disease. The role of these cells in cancer settings has been widely debated. …
cells in allergic disease. The role of these cells in cancer settings has been widely debated. …
Curcumin causes superoxide anion production and p53-independent apoptosis in human colon cancer cells
…, M Walsh, PW Lee, CA Giacomantonio… - Cancer letters, 2010 - Elsevier
Curcumin from the rhizome of theCurcuma longa plant has chemopreventative activity and
inhibits the growth of neoplastic cells. Since p53 has been suggested to be important for …
inhibits the growth of neoplastic cells. Since p53 has been suggested to be important for …
Curcumin‐induced apoptosis in ovarian carcinoma cells is p53‐independent and involves p38 mitogen‐activated protein kinase activation and downregulation of Bcl …
…, A Hilchie, PW Lee, CA Giacomantonio… - … in cooperation with …, 2010 - Wiley Online Library
New cytotoxic agents are urgently needed for the treatment of advanced ovarian cancer
because of the poor long‐term response of this disease to conventional chemotherapy. …
because of the poor long‐term response of this disease to conventional chemotherapy. …
[HTML][HTML] Aldehyde dehydrogenase 1A3 influences breast cancer progression via differential retinoic acid signaling
…, EG Mathenge, SA Gujar, CA Giacomantonio… - Molecular …, 2015 - Elsevier
Aldehyde dehydrogenase (ALDH) 1A enzymes produce retinoic acid (RA), a transcription
induction molecule. To investigate if ALDH1A1 or ALDH1A3-mediated RA signaling has an …
induction molecule. To investigate if ALDH1A1 or ALDH1A3-mediated RA signaling has an …
[HTML][HTML] Core needle biopsy of breast cancer tumors increases distant metastases in a mouse model
…, SA Gujar, P Marcato, PWK Lee, CA Giacomantonio - Neoplasia, 2014 - Elsevier
INTRODUCTION: Incisional biopsies, including the diagnostic core needle biopsy (CNB),
routinely performed before surgical excision of breast cancer tumors are hypothesized to …
routinely performed before surgical excision of breast cancer tumors are hypothesized to …
[HTML][HTML] Citral reduces breast tumor growth by inhibiting the cancer stem cell marker ALDH1A3
…, MA Giacomantonio, CA Giacomantonio… - Molecular …, 2016 - Elsevier
Breast cancer stem cells (CSCs) can be identified by increased Aldefluor fluorescence
caused by increased expression of aldehyde dehydrogenase 1A3 (ALDH1A3), as well as …
caused by increased expression of aldehyde dehydrogenase 1A3 (ALDH1A3), as well as …
[HTML][HTML] Oncolytic reovirus effectively targets breast cancer stem cells
P Marcato, CA Dean, CA Giacomantonio, PWK Lee - Molecular Therapy, 2009 - cell.com
Recent evidence suggests that cancer stem cells (CSCs) play an important role in cancer,
as these cells possess enhanced tumor-forming capabilities and are resistant to current …
as these cells possess enhanced tumor-forming capabilities and are resistant to current …
Curcumin-induced apoptosis in PC3 prostate carcinoma cells is caspase-independent and involves cellular ceramide accumulation and damage to mitochondria
…, MRJ Robichaud, CA Giacomantonio… - Nutrition and …, 2010 - Taylor & Francis
Curcumin, the principal curcuminoid of tumeric, has potent anticancer activity. To determine
the mechanism of curcumin-induced cytotoxicity in prostate cancer cells, we exposed PC3 …
the mechanism of curcumin-induced cytotoxicity in prostate cancer cells, we exposed PC3 …