Tumors of mesenchymal and epithelial origin produce IGF-2, which activates pathways in
the tumors. In a minority of patients, the tumors (hepatomas, fibromas, and fibrosarcomas are …

Modern imaging modalities lead to frequent detection of adrenal masses, most of them
incidental findings. Although the majority of adrenocortical and adrenomedullary tumors are …

Understanding of molecular mechanisms of tumor growth has an increasing impact on the
development of diagnostics and targeted therapy of human neoplasia. In this review, we …

Src homology (SH) regions 2 and 3 are noncatalytic domains that are conserved among a
series of cytoplasmic signaling proteins regulated by receptor protein-tyrosine kinases, …

Background Well-written and transparent case reports (1) reveal early signals of potential
benefits, harms, and information on the use of resources; (2) provide information for clinical …

… we did not calibrate signals in terms of free Ca concentration. 14. DC Ogden, T. … (NCIC)
and the Medical Research Council of Canada (MRC). DA and MFM are postdoctoral fellows of …

… is a Terry Fox Cancer Research Scientist of the National Cancer Institute of Canada. CAK
and LE hold student fellowships from the Medical Research Council of Canada and the …

Kinetochore reorientation is the critical process ensuring normal chromosome distribution.
Reorientation has been studied in living grasshopper spermatocytes, in which bivalents with …

Objective To define associated clinical conditions, pathology, natural history, and treatment
outcome of nonhepatosplenic extramedullary hematopoiesis (NHS-EMH). Patients and …

Context: Germline mutations in the MEN1 gene predispose to multiple endocrine neoplasia
type 1 (MEN1) syndrome, but in up to 20–25% of clinical MEN1 cases, no MEN1 mutations …