User profiles for Carman A. Giacomantonio
 | Carman GiacomantonioProfessor of Surgery, Dalhousie University Verified email at dal.ca Cited by 3289 |
Aldehyde dehydrogenase: its role as a cancer stem cell marker comes down to the specific isoform
P Marcato, CA Dean, CA Giacomantonio, PWK Lee - Cell cycle, 2011 - Taylor & Francis
Recent evidence suggests that enhanced aldehyde dehydrogenase (ALDH) activity is a
hallmark of cancer stem cells (CSC) measurable by the aldefluor assay. ALDH1A1, one of 19 …
hallmark of cancer stem cells (CSC) measurable by the aldefluor assay. ALDH1A1, one of 19 …
Aldehyde dehydrogenase activity of breast cancer stem cells is primarily due to isoform ALDH1A3 and its expression is predictive of metastasis
…, L Pan, A Leidal, S Gujar, CA Giacomantonio… - Stem …, 2011 - academic.oup.com
Cancer stem cells (CSCs) are proposed to initiate cancer and propagate metastasis. Breast
CSCs identified by aldehyde dehydrogenase (ALDH) activity are highly tumorigenic in …
CSCs identified by aldehyde dehydrogenase (ALDH) activity are highly tumorigenic in …
Curcumin‐induced apoptosis in ovarian carcinoma cells is p53‐independent and involves p38 mitogen‐activated protein kinase activation and downregulation of Bcl …
…, A Hilchie, PW Lee, CA Giacomantonio… - … in cooperation with …, 2010 - Wiley Online Library
New cytotoxic agents are urgently needed for the treatment of advanced ovarian cancer
because of the poor long‐term response of this disease to conventional chemotherapy. …
because of the poor long‐term response of this disease to conventional chemotherapy. …
Curcumin causes superoxide anion production and p53-independent apoptosis in human colon cancer cells
…, M Walsh, PW Lee, CA Giacomantonio… - Cancer letters, 2010 - Elsevier
Curcumin from the rhizome of theCurcuma longa plant has chemopreventative activity and
inhibits the growth of neoplastic cells. Since p53 has been suggested to be important for …
inhibits the growth of neoplastic cells. Since p53 has been suggested to be important for …
[HTML][HTML] Aldehyde dehydrogenase 1A3 influences breast cancer progression via differential retinoic acid signaling
…, EG Mathenge, SA Gujar, CA Giacomantonio… - Molecular …, 2015 - Elsevier
Aldehyde dehydrogenase (ALDH) 1A enzymes produce retinoic acid (RA), a transcription
induction molecule. To investigate if ALDH1A1 or ALDH1A3-mediated RA signaling has an …
induction molecule. To investigate if ALDH1A1 or ALDH1A3-mediated RA signaling has an …
[HTML][HTML] Core needle biopsy of breast cancer tumors increases distant metastases in a mouse model
…, S Photopoulos, KM Coyle, M Giacomantonio… - Neoplasia, 2014 - Elsevier
INTRODUCTION: Incisional biopsies, including the diagnostic core needle biopsy (CNB),
routinely performed before surgical excision of breast cancer tumors are hypothesized to …
routinely performed before surgical excision of breast cancer tumors are hypothesized to …
[HTML][HTML] Citral reduces breast tumor growth by inhibiting the cancer stem cell marker ALDH1A3
…, MA Giacomantonio, CA Giacomantonio… - Molecular …, 2016 - Elsevier
Breast cancer stem cells (CSCs) can be identified by increased Aldefluor fluorescence
caused by increased expression of aldehyde dehydrogenase 1A3 (ALDH1A3), as well as …
caused by increased expression of aldehyde dehydrogenase 1A3 (ALDH1A3), as well as …
[HTML][HTML] Oncolytic reovirus effectively targets breast cancer stem cells
P Marcato, CA Dean, CA Giacomantonio, PWK Lee - Molecular Therapy, 2009 - cell.com
Recent evidence suggests that cancer stem cells (CSCs) play an important role in cancer,
as these cells possess enhanced tumor-forming capabilities and are resistant to current …
as these cells possess enhanced tumor-forming capabilities and are resistant to current …
Curcumin-induced apoptosis in PC3 prostate carcinoma cells is caspase-independent and involves cellular ceramide accumulation and damage to mitochondria
…, MRJ Robichaud, CA Giacomantonio… - Nutrition and …, 2010 - Taylor & Francis
Curcumin, the principal curcuminoid of tumeric, has potent anticancer activity. To determine
the mechanism of curcumin-induced cytotoxicity in prostate cancer cells, we exposed PC3 …
the mechanism of curcumin-induced cytotoxicity in prostate cancer cells, we exposed PC3 …
Malignant triton tumors—complete surgical resection and adjuvant radiotherapy associated with improved survival
…, CA Giacomantonio - Journal of surgical …, 2012 - Wiley Online Library
Background Malignant triton tumors (MTT) are a rare form of peripheral nerve sheath tumors
that follows a particularly aggressive course. Given its rarity, only case reports and small …
that follows a particularly aggressive course. Given its rarity, only case reports and small …