Tau pathology reduction with SM07883, a novel, potent, and selective oral DYRK1A inhibitor: A potential therapeutic for Alzheimer's disease
B Melchior, GK Mittapalli, C Lai, K Duong‐Polk… - Aging cell, 2019 - Wiley Online Library
Dual‐specificity tyrosine phosphorylation‐regulated kinase‐1A (DYRK1A) is known to
phosphorylate the microtubule‐associated tau protein. Overexpression is correlated with tau …
phosphorylate the microtubule‐associated tau protein. Overexpression is correlated with tau …
[HTML][HTML] Ventriculopleural shunts in a pediatric population: a review of 170 consecutive patients
EA Christian, JJ Quezada, EF Melamed, C Lai… - Journal of …, 2021 - thejns.org
OBJECTIVE The authors sought to determine the outcome of using the pleural space as the
terminus for ventricular CSF-diverting shunts in a pediatric population. METHODS All …
terminus for ventricular CSF-diverting shunts in a pediatric population. METHODS All …
High-fidelity virtual reality simulation for the middle cranial fossa approach—modules for surgical rehearsal and education
C Lai, JT Lui, JM Chen, VY Lin, SK Agrawal… - Operative …, 2022 - journals.lww.com
BACKGROUND: Virtual reality simulation has gained prominence as a valuable surgical
rehearsal and education tool in neurosurgery. Approaches to the internal auditory canal, …
rehearsal and education tool in neurosurgery. Approaches to the internal auditory canal, …
[HTML][HTML] The user experience design of a novel microscope within SurgiSim, a virtual reality surgical simulator
…, A Volpato Batista, C Lai… - International Journal of …, 2023 - Springer
Purpose Virtual reality (VR) simulation has the potential to advance surgical education,
procedural planning, and intraoperative guidance. “SurgiSim” is a VR platform developed for the …
procedural planning, and intraoperative guidance. “SurgiSim” is a VR platform developed for the …
[HTML][HTML] A phase II pilot randomized controlled trial to assess the feasibility of the “supra-marginal” surgical resection of malignant glioma (G-SUMIT: Glioma supra …
A Mansouri, C Lai, D Scales, F Pirouzmand - Pilot and feasibility studies, 2022 - Springer
Background High-grade gliomas are the most common primary malignant brain tumor in
adults having a median survival of only 13–16 months. This is despite the current standard of …
adults having a median survival of only 13–16 months. This is despite the current standard of …
[HTML][HTML] The role of botulinum toxin a in the establishment of symmetry in pediatric paralysis of the lower lip
S Haykal, E Arad, S Bagher, C Lai… - JAMA Facial Plastic …, 2015 - liebertpub.com
… Carolyn Lai, … Carolyn Lai … Siba Haykal, Ehud Arad, Shaghayegh Bagher, Carolyn Lai,
Marc Hohman, Tessa Hadlock, Ronald M. Zuker, and Gregory H. Borschel.…
Marc Hohman, Tessa Hadlock, Ronald M. Zuker, and Gregory H. Borschel.…
[HTML][HTML] Endoscopic Treatment of Rathke's Cleft Cysts: The Case for Simple Fenestration
Background: Rathke’s cleft cysts (RCC) arise from the pars intermedia because of incomplete
regression of the embryologic Rathke pouch. A subset of RCC becomes symptomatic …
regression of the embryologic Rathke pouch. A subset of RCC becomes symptomatic …
[HTML][HTML] Machine-vision image guided C4-C5 unilateral cervical pedicle screw insertion: case report and review of literature
Computer-assistance for pedicle screw insertion is becoming increasingly common. As in
the case presented below, image guided neuronavigation can be used to improve the …
the case presented below, image guided neuronavigation can be used to improve the …
[HTML][HTML] Malignant Cerebellopontine Angle Peripheral Nerve Sheath Tumor with Divergent Mesenchymal (Cartilaginous) Differentiation Presenting with Catastrophic …
C Lai, D Bajin, JM Chen, BC Dickson… - The Journal of …, 2023 - ncbi.nlm.nih.gov
Malignant peripheral nerve sheath tumors of the cerebellopontine angle are rare, especially
even outside of the context of neurofibromatosis or malignant transformation of previously …
even outside of the context of neurofibromatosis or malignant transformation of previously …
Timeliness to definitive treatment to avoid severe neurologic complications associated with spontaneous intracranial hypotension
P Hong, A Kapadia, C Lai, W Kingston… - Canadian Journal of …, 2023 - Springer
To the Editor, Spontaneous intracranial hypotension (SIH) presents with neurologic symptoms
including headaches, dizziness, diplopia, behavioural changes, and altered mental status …
including headaches, dizziness, diplopia, behavioural changes, and altered mental status …
