Diffusion tensor imaging shows mechanism-specific differences in injury pattern and progression in rat models of acute spinal cord injury

A Yung, S Mattucci, B Bohnet, J Liu, C Fournier… - Neuroimage, 2019 - Elsevier
We investigate the ability of diffusion tensor imaging (DTI) to distinguish between three
experimental rat models of spinal cord injury mechanism – contusion, dislocation, and distraction. …

Advanced MRI biomarkers of the injured spinal cord–a comparative study of imaging and histology in human traumatic SCI

…, P Kozlowski, Z Samadi-Bahrami, C Fournier… - Journal of …, 2024 - liebertpub.com
A significant problem in the diagnosis and treatment of traumatic spinal cord injury (tSCI) is
the heterogeneity of secondary injury and the prediction of neurologic outcome. Imaging …

Correlating advanced MRI and histopathological measurements of axons and myelin in human traumatic spinal cord injury

…, A Bauman, P Kozlowski, F Samadi, C Fournier… - archive.ismrm.org
Using human spinal cord tissue donated to the International Spinal Cord Injury Biobank, we
quantitatively correlated binarized histological stains for myelin and axons with myelin-and …

Advanced Magnetic Resonance techniques in Post-Mortem Human Spinal Cord Injury: Correlations with Histopathology

…, A Yung, A Bauman, Z Samadi, CS Fournier… - archive.ismrm.org
Spinal cord injury prognosis assessments rely on subjective clinical evaluations and often
poorly predict outcome; quantitative imaging biomarkers for spinal cord injury evaluation …

Inhomogeneous Magnetization Transfer and DBSI detect downstream white matter damage in post-mortem human cervical spinal cord injury

…, P Kozlowski, A Bauman, F Samadi, C Fournier… - archive.ismrm.org
Spinal cord injuries are heterogeneous, with complex microstructure which changes over
time. We used 7T Diffusion Tensor Imaging (DTI), Diffusion Basis Spectrum Imaging (DBSI) …

Identifying diffusion model biomarkers for inflammation in human traumatic spinal cord injury

…, A Bauman, P Kozlowski, F Samadi, C Fournier… - archive.ismrm.org
We investigated the relationship between diffusion model biomarkers and inflammatory cells,
as measured by HLA-DR and CD68 histological staining for activated microglia and …

Myelin-sensitive MRI metrics correlate with inflammation in human traumatic spinal cord injury

…, A Bauman, P Kozlowski, F Samadi, C Fournier… - archive.ismrm.org
We investigated the correlation of inhomogeneous magnetisation transfer ratio (ihMTR), myelin
water fraction (MWF) and intra/extra-cellular water geometric mean T 2 (I/EW gmT 2) with …

Paleoproterozoic sterol biosynthesis and the rise of oxygen

DA Gold, A Caron, GP Fournier, RE Summons - Nature, 2017 - nature.com
Natural products preserved in the geological record can function as ‘molecular fossils’,
providing insight into organisms and physiologies that existed in the deep past. One important …

[HTML][HTML] CdGAP/ARHGAP31, a Cdc42/Rac1 GTPase regulator, is critical for vascular development and VEGF-mediated angiogenesis

C Caron, J DeGeer, P Fournier, PM Duquette… - Scientific Reports, 2016 - nature.com
Mutations in the CdGAP/ARHGAP31 gene, which encodes a GTPase-activating protein for
Rac1 and Cdc42, have been reported causative in the Adams-Oliver developmental …

Use of adrenomedullin derivatives for molecular imaging of pulmonary circulation

…, LP Perrault, A Caron, A Fournier… - Journal of Nuclear …, 2008 - Soc Nuclear Med
Currently, there is no low-molecular-weight agent for imaging of the pulmonary circulation.
Adrenomedullin (AM) is a peptide predominantly cleared by the pulmonary circulation …