Glucocorticoids in osteonecrosis of the femoral head: a new understanding of the mechanisms of action

MA Kerachian, C Séguin, EJ Harvey - The Journal of steroid biochemistry …, 2009 - Elsevier
Glucocorticoid (GC) usage is the most common non-traumatic cause of osteonecrosis of the
femoral head (ON). Despite the strong association of GC with ON, the underlying …

Avascular necrosis of the femoral head: vascular hypotheses

…, EJ Harvey, D Cournoyer, TYK Chow, C Séguin - Endothelium, 2006 - Taylor & Francis
Vascular hypotheses provide compelling pathogenic mechanisms for the etiology of avascular
necrosis of the femoral head (ANFH). A decrease in local blood flow of the femoral head …

[HTML][HTML] Short term clinical outcome of a porous tantalum implant for the treatment of advanced osteonecrosis of the femoral head

M Nadeau, C Séguin, JS Theodoropoulos… - McGill Journal of …, 2007 - ncbi.nlm.nih.gov
Purpose of the study: Osteonecrosis of the hip mostly affects young individuals and often
progresses to a debilitating disease. Several treatment modalities exist, but none are …

The PETALE study: Late adverse effects and biomarkers in childhood acute lymphoblastic leukemia survivors

…, P Robaey, M Samoilenko, C Séguin… - Pediatric blood & …, 2017 - Wiley Online Library
Background Childhood cancer survivorship issues represent an established public health
challenge. Most late adverse effects (LAEs) have been demonstrated to be time and treatment …

Antithrombotic agents and traumatic brain injury in the elderly population: hemorrhage patterns and outcomes

P Scotti, C Séguin, BWY Lo, E De Guise… - Journal of …, 2019 - thejns.org
OBJECTIVE Among the elderly, use of antithrombotics (ATs), antiplatelets (APs; aspirin,
clopidogrel), and/or anticoagulants (ACs; warfarin, direct oral ACs [DOACs; dabigatran, …

[HTML][HTML] New insights into the pathogenesis of glucocorticoid-induced avascular necrosis: microarray analysis of gene expression in a rat model

…, TY Chow, LR Bégin, A Nahal, C Séguin - Arthritis research & …, 2010 - Springer
Introduction Avascular necrosis of the femoral head (ANFH) occurs variably after exposure to
corticosteroids. Microvascular thrombosis is a common pathological finding. Since systemic …

Effect of high-dose dexamethasone on endothelial haemostatic gene expression and neutrophil adhesion

…, TY Chow, PE Neagoe, MG Sirois, C Séguin - The Journal of steroid …, 2009 - Elsevier
Glucocorticoid usage especially at high doses is complicated by adverse outcomes such as
thrombotic events or acceleration of inflammatory response in conditions like myeloma and …

Predicting Environmental Behaviors: The Influence of Self‐Determined Motivation and Information About Perceived Environmental Health Risks1

C Seguin, LG Pelletier, J Hunsley - Journal of Applied Social …, 1999 - Wiley Online Library
The purpose of the present study is to examine the combined contribution of 2 predictors of
environmental behaviors, self‐determined motivation and information about a particular …

[HTML][HTML] A rat model of early stage osteonecrosis induced by glucocorticoids

…, D Cournoyer, TY Chow, A Nahal, C Séguin - Journal of orthopaedic …, 2011 - Springer
Background Glucocorticoid (GC)-induced osteonecrosis (ON) is an important complication of
medical therapy. The exact pathomechanisms of ON has not been clearly elucidated. There …

Osteonecrosis of the femoral head: genetic basis

…, W Mah, EJ Harvey, D Rosenblatt, C Séguin - International …, 2019 - Springer
Purpose Genetic factors and hereditary forms of osteonecrosis of the femoral head (ONFH)
have been elucidated through genetic association studies. The significance of these cases is …