It has been known for many years that neutrophils and platelets participate in the pathogenesis
of severe sepsis, but the inter-relationship between these players is completely unknown. …

Background Some observational studies suggest that the use of pulmonary-artery catheters
to guide therapy is associated with increased mortality. Methods We performed a …

Context The expression and release of tissue factor is a major trigger for the activation of
coagulation in patients with sepsis. Tissue factor pathway inhibitor (TFPI) forms a complex with …

Introduction Severe acute renal failure (sARF) is associated with considerable morbidity,
mortality and use of healthcare resources; however, its precise epidemiology and long-term …

We conducted a prospective, observational cohort study designed to compare intestinal
permeability (IP) and development of multiple organ dysfunction syndrome (MODS) in a subset …

Critically ill patients in intensive care units experience profound alterations of their gut
microbiota that have been linked to a high risk of hospital-acquired (nosocomial) infections and …

Objective: To evaluate whether administration of afelimomab, an anti-tumor necrosis factor F
(ab′) 2 monoclonal antibody fragment, would reduce 28-day all-cause mortality in patients …

Objective: To describe the incidence of non-neurologic organ dysfunction and its association
with outcome in patients with severe traumatic brain injury admitted to intensive care. …

Objective Acute renal failure can be treated with continuous renal replacement therapy (CRRT)
or intermittent hemodialysis. There is no difference in mortality, although patients treated …

Objective: To provide further evidence for the efficacy and safety of drotrecogin alfa (activated)
treatment in severe sepsis. Design: Single-arm, open-label, trial of drotrecogin alfa (…