Perturbations in mitochondrial health may foster age-related losses of aerobic capacity (VO
2peak ) and skeletal muscle size. However, limited data exist regarding mitochondrial …

Metformin and exercise independently improve insulin sensitivity and decrease the risk of
diabetes. Metformin was also recently proposed as a potential therapy to slow aging. However…

Cellular circadian clocks direct a daily transcriptional program that supports homeostasis
and resilience. Emerging evidence has demonstrated age-associated changes in circadian …

The total amount of blood flow circulating through the heart, lungs and all the tissues of the
body represents the cardiac output. Most individual tissues determine their own flow in …

The development of antiviral agents is one of the major challenges in medical science. So
far, small monovalent molecular drugs that inhibit the late steps in the viral replication cycle, ie…

This article presents a new model for describing well-position uncertainties. An analysis for
surveying position uncertainties. An analysis for surveying errors is given that demonstrates …

Key points Disruptions in circadian rhythms across an organism are associated with negative
health outcomes, such as cardiometabolic and neurodegenerative diseases. Exercise has …

10.7554/eLife.43017.001 In the present study we show that the master myogenic regulatory
factor, MYOD1, is a positive modulator of molecular clock amplitude and functions with the …

Intermuscular adipose tissue (IMAT) is associated with impaired skeletal muscle contractile
and metabolic function. Myostatin and downstream signaling proteins such as cyclin-…

Advances in stable isotope approaches, primarily the use of deuterium oxide ( 2 H 2 O), allow
for long-term measurements of protein synthesis, as well as the contribution of individual …