Background Frailty is an emerging risk factor for surgical outcomes; however, its application
across large populations is not well defined. We hypothesized that frailty affects …

The main objective of this study was to determine the cellular and molecular effects of
doxycycline on the blood–brain barrier (BBB) and protection against secondary injuries following …

Hydrogen peroxide (H 2 O 2 ) plays an important role physiologically as the second
messenger and pathologically as an inducer of oxidative stress in injury, ischemia and other …

BACKGROUND: A new proprietary negative pressure wound device has been developed to
apply negative pressure therapy to closed wounds (closed-NPWT). We postulated that …

Background Laparoscopic appendectomy is typically associated with inpatient hospitalization
averaging between 1 and 2 days. In July 2010, a prospective protocol for outpatient …

Background We hypothesized that the universal adoption of closed wounds with negative
pressure wound therapy (NPWT) in emergency general surgery patients would result in low …

BACKGROUND Many military and civilian centers have shifted to a damage-control
resuscitation approach, focused on providing oxygen-carrying capacity while simultaneously …

Background General surgery training has historically lacked a standardized approach to
resident quality improvement (QI) education aside from traditional morbidity and mortality …

Background: End-of-life (EoL) care after geriatric burns (geri-burns) is understudied. Objective:
To examine the practices of burn surgeons for initiating EoL discussions and the impact …

BACKGROUND: The CDC reported in 2017 that the largest increments in probability of
continued use were observed after days 5 and 31 on opioid therapy. This study demonstrates the …