Receiving both portal vein blood and arterial blood, the liver is an important and critical
component in the defense against blood-borne infection. To accomplish this role, the liver …

The liver is a key, frontline immune tissue. Ideally positioned to detect pathogens entering the
body via the gut, the liver appears designed to detect, capture, and clear bacteria, viruses, …

Neutrophil extracellular traps (NETs) are released as neutrophils die in vitro in a process
requiring hours, leaving a temporal gap that invasive microbes may exploit. Neutrophils …

Chronic infection is difficult to overcome because of exhaustion or depletion of cytotoxic
effector CD8 + T cells (cytotoxic T lymphoytes (CTLs)). Here we report that signaling via Toll-like …

Neutrophil extracellular traps (NETs; webs of DNA coated in antimicrobial proteins) are released
into the vasculature during sepsis where they contribute to host defense, but also cause …

Neutrophils mediate bacterial clearance through various mechanisms, including the release
of mesh-like DNA structures or neutrophil extracellular traps (NETs) that capture bacteria. …

From an evolutionary perspective, neutrophils are one of oldest immune cell types and
represent a key first responder to infection and tissue injury (Leiding 2017). These early immune …

During the systemic inflammatory response of severe sepsis, neutrophils accumulate in the
liver microcirculation, but their functional significance is largely unknown. We show that …

Neutrophil extracellular traps (NETs) composed of DNA decorated with histones and proteases
trap and kill bacteria but also injure host tissue. Here we show that during a bloodstream …

Monocytes are recruited from the blood to sites of inflammation, where they contribute to
wound healing and tissue repair. There are at least two subsets of monocytes: classical or …