User profiles for D. Ghazarian

Danny Ghazarian

Professor, University Of Toronto
Verified email at uhn.ca
Cited by 4195

Skin adnexal neoplasms—part 2: an approach to tumours of cutaneous sweat glands

NA Obaidat, KO Alsaad, D Ghazarian - Journal of Clinical Pathology, 2007 - jcp.bmj.com
… (D) In situ component adjacent to the invasive porocarcinoma depicted in (B) and (C). …
Syringocystadenocarcinoma papilliferum (fig 8C,D) is very rare, and as characterised …

Skin adnexal neoplasms—part 1: an approach to tumours of the pilosebaceous unit

KO Alsaad, NA Obaidat, D Ghazarian - Journal of clinical pathology, 2007 - jcp.bmj.com
D Ghazarian … on haematoxylin and eosin stain (A and B) and CD34-positive stroma (C),
shown to have the immunostaining pattern of basal cell carcinoma with diffusely positive bcl-2 (D)…

Primary frozen section diagnosis by robotic microscopy and virtual slide telepathology: the University Health Network experience

…, R Chetty, BA Clarke, S Croul, DM Ghazarian… - Seminars in diagnostic …, 2009 - Elsevier
Although telepathology (TP) has not been widely implemented for primary frozen section
diagnoses, interest in its use is growing as we move into an age of increasing sub-…

Mule/Huwe1/Arf-BP1 suppresses Ras-driven tumorigenesis by preventing c-Myc/Miz1-mediated down-regulation of p21 and p15

…, S McCracken, A Wakeham, D Ghazarian… - Genes & …, 2013 - genesdev.cshlp.org
… (B) The proliferation of the siRNA-expressing keratinocytes in A was analyzed by counting
cell numbers at 2 and 4 d post-seeding. Data are the mean ± SD of six cultures per group. P-…

[HTML][HTML] Phase II clinical trial of adoptive cell therapy for patients with metastatic melanoma with autologous tumor-infiltrating lymphocytes and low-dose interleukin-2

…, D Ghazarian, L Bonilla, H Majeed, D Hogg… - Cancer Immunology …, 2019 - Springer
Adoptive cell therapy using autologous tumor-infiltrating lymphocytes (TIL) has shown
significant clinical benefit, but is limited by toxicities due to a requirement for post-infusion …

Early onset of neoplasia in the prostate and skin of mice with tissue-specific deletion of Pten

SA Backman, D Ghazarian, K So… - Proceedings of the …, 2004 - National Acad Sciences
… Epidermis of Pten loxP/loxP ; MMTV-cre mice is papillary in appearance (D). Acanthosis with
hyperkeratosis and hypergranulosis are apparent in Pten mutant skin (F). Skin from control …

Regulatory T cells in ovarian cancer are characterized by a highly activated phenotype distinct from that in melanoma

…, SR Katz, PA Shaw, BA Clarke, D Ghazarian… - Clinical Cancer …, 2018 - AACR
Purpose: Regulatory T (Treg) cells expressing the transcription factor FOXP3 are essential
for the maintenance of immunologic self-tolerance but play a detrimental role in most cancers …

[HTML][HTML] Expansion and characterization of human melanoma tumor-infiltrating lymphocytes (TILs)

LT Nguyen, PH Yen, J Nie, N Liadis, D Ghazarian… - PloS one, 2010 - journals.plos.org
Background Various immunotherapeutic strategies for cancer are aimed at augmenting the
T cell response against tumor cells. Adoptive cell therapy (ACT), where T cells are …

Epidemiological features and prognostic factors of cutaneous head and neck melanoma: a population-based study

A Golger, DS Young, D Ghazarian… - … –Head & Neck Surgery, 2007 - jamanetwork.com
… reports; (c) records of patients referred to 8 Regional Cancer Centers and the Princess
Margaret Hospital, which specializes in treating patients with cancer in Ontario; and (d) death …

Gene of the month: BAP1

…, M Hyrcza, A Al-Habeeb, D Ghazarian - Journal of Clinical …, 2016 - jcp.bmj.com
The BAP1 gene (BRCA1-associated protein 1) is a tumour suppressor gene that encodes a
deubiquitinating enzyme (DUB), regulating key cellular pathways, including cell cycle, …