… Central sensitization is largely mediated by the N-methyl-D-aspartate (NMDA) receptor.
Although experimental NMDA-receptor blockade clearly suppresses central sensitization,65 …

Two of the most difficult problems in evaluating treatment efficacy in pain research involve
what constitutes a ‘‘successful’’outcome and how best to measure it (Turk et al., 2003). …

Secukinumab, ixekizumab and brodalumab are monoclonal antibody therapies that inhibit
interleukin (IL)-17 activity and are widely used for the treatment of psoriasis, psoriatic arthritis …

… les degrés probants d’efficacité analgésique, d’innocuité, de facilité d’utilisation et … d’après
l’efficacité, le profil d’effets secondaires et l’accessibilité du médicament, y compris le coût. D’…

… de la DNe ont été évaluées lors d’une réunion de consensus en … des preuves d’efficacité
analgésique, d’innocuité et de facilité d’… tenu de l’efficacité, du profil d’effets secondaires et de l’…

… d’absence du travail pour cause de douleur chronique au cours de la dernière année s’élevait
à 9,3. INTERPRÉTATION : La douleur chronique non cancéreuse touche beaucoup d’…

… , the level of evidence available, other than for more recent drug studies, is mostly poor or
lacking completely, with more than two-thirds of the recommendations graded as either level D …

Background: Painful neuropathy is one of the most common long-term complications of diabetes
mellitus and often proves difficult to relieve. Methods: Patients with diabetic neuropathy …

Background The use of opioid analgesics for chronic non-cancer pain is controversial. Some
surveys report good pain relief and improvement in performance while others suggest a …

IL-33 (or IL-1F11) was recently identified as a ligand for the previously orphaned IL-1 family
receptor T1/ST2. Previous studies have established that IL-33 and T1/ST2 exert key …