The 2015 update of the Canadian Stroke Best Practice Recommendations Hyperacute Stroke
Care guideline highlights key elements involved in the initial assessment, stabilization, …

… Menon, Brian Moses, Melanie Penn, Jeff Perry, Elizabeth Snieder, and Dawn Tymianski
are all members of the Acute Inpatient Stroke Care expert writing group and contributed by …

Background Sporadic arteriovenous malformations of the brain, which are morphologically
abnormal connections between arteries and veins in the brain vasculature, are a leading …

With a growing population of older adults living with dementia in the community, nurse
practitioners (NPs) are increasingly expected to address issues of medical fitness to drive (MFTD) …

Traditional models of neuronal excitotoxicity focused on the overactivation of receptors such
as the ionotropic N-methyl-d-aspartate (NMDA)-subtype glutamate receptor. Recent …

… Author links open overlay panel Kinga Szydlowska a b , Michael Tymianski a b c d …
expressed NR1 subunit, four distinct NR2 subunits (A–D), and two NR3 members (A and B) [17]. …

… -mediated excitotoxicity with specific focus on (i) the role of Ca 2+ in neurotoxicity, (ii) The
concept of ‘source specificity’ of neurotoxicity, (iii) the role of the ionotropic N-methyl-D-…

The efficiency with whichN-methyl-d-aspartate receptors (NMDARs) trigger intracellular
signaling pathways governs neuronal plasticity, development, senescence, and disease. In …

N-methyl-d-aspartate receptors (NMDARs) mediate ischemic brain damage but also mediate
essential neuronal excitation. To treat stroke without blocking NMDARs, we transduced …

… resistant to protease degradation by substituting l- for d-amino acids. In so doing, we
generated a peptide termed d-Tat-l-2B9c comprising 11 d-amino acids of Tat fused to the 9 l-amino …