User profiles for Danielle Macneil
 | Danielle MacneilWestern University Verified email at lhsc.on.ca Cited by 4593 |
[HTML][HTML] Troponin T monitoring to detect myocardial injury after noncardiac surgery: a cost–consequence analysis
…, MJ Jacka, M Tiboni, G Ackland, D Macneil… - Canadian Journal of …, 2018 - ncbi.nlm.nih.gov
Background Myocardial injury after noncardiac surgery (MINS) is a mostly asymptomatic
condition that is strongly associated with 30-day mortality; however, it remains mostly …
condition that is strongly associated with 30-day mortality; however, it remains mostly …
Oncologic significance of therapeutic delays in patients with oral cavity cancer
Importance Oral cavity cancer often requires multidisciplinary management, subjecting
patients to complex therapeutic trajectories. Prolonged treatment intervals in oral cavity cancer …
patients to complex therapeutic trajectories. Prolonged treatment intervals in oral cavity cancer …
ERK-TSC2 signalling in constitutively-active HRAS mutant HNSCC cells promotes resistance to PI3K inhibition
Objectives The PI3K/AKT/mTOR pathway is frequently altered in head and neck squamous
cell cancer (HNSCC), making this pathway a logical therapeutic target. However, PI3K …
cell cancer (HNSCC), making this pathway a logical therapeutic target. However, PI3K …
Disruption of the RICTOR/mTORC2 complex enhances the response of head and neck squamous cell carcinoma cells to PI3K inhibition
Phosphoinositide 3‐kinase (PI3K) is aberrantly activated in head and neck squamous cell
carcinomas (HNSCC) and plays a pivotal role in tumorigenesis by driving Akt signaling, …
carcinomas (HNSCC) and plays a pivotal role in tumorigenesis by driving Akt signaling, …
[HTML][HTML] Immune-based classification of HPV-associated oropharyngeal cancer with implications for biomarker-driven treatment de-intensification
…, SD da Silva, M Hier, H Khan, D MacNeil… - …, 2022 - thelancet.com
Background There is significant interest in treatment de-escalation for human papillomavirus-associated
(HPV + ) oropharyngeal squamous cell carcinoma (OPSCC) patients given the …
(HPV + ) oropharyngeal squamous cell carcinoma (OPSCC) patients given the …
All HPV-negative head and neck cancers are not the same: Analysis of the TCGA dataset reveals that anatomical sites have distinct mutation, transcriptome, hypoxia …
Purpose Head and neck squamous cell carcinoma (HNSCC) affects various anatomical sites,
which often dictates whether the cancer is managed with primary surgery or radiation. This …
which often dictates whether the cancer is managed with primary surgery or radiation. This …
[HTML][HTML] Repurposing Albendazole: new potential as a chemotherapeutic agent with preferential activity against HPV-negative head and neck squamous cell cancer
Albendazole is an anti-helminthic drug that has been shown to exhibit anti-cancer properties,
however its activity in head and neck squamous cell cancer (HNSCC) was unknown. Using …
however its activity in head and neck squamous cell cancer (HNSCC) was unknown. Using …
Sex disparities in head & neck cancer driver genes: An analysis of the TCGA dataset
Objectives Survival in head and neck squamous cell carcinoma (HNSCC) has been associated
with patient sex, typically with males experiencing poorer outcomes. It is unclear if this …
with patient sex, typically with males experiencing poorer outcomes. It is unclear if this …
Variable expression of the forgotten oncogene E5 in HPV-positive oropharyngeal cancer
Background The role of the HPV E6/E7 oncogenes in head and neck squamous cell cancer
(HNSCC) has been studied extensively, but the role of the viral E5 protein remains poorly …
(HNSCC) has been studied extensively, but the role of the viral E5 protein remains poorly …
[HTML][HTML] Mutational analysis of head and neck squamous cell carcinoma stratified by smoking status
Smoking has historically been recognized as a negative prognostic factor in head and neck
squamous cell carcinoma (HNSCC). This study aimed to assess the mutational differences …
squamous cell carcinoma (HNSCC). This study aimed to assess the mutational differences …