Two helper-dependent (HD) adenoviral vectors encoding a canine factor VIII B-domain–deleted
transgene (cFVIII) were constructed and evaluated in 4 hemophilia A dogs. One vector …

G M2 gangliosidoses are severe neurodegenerative disorders resulting from a deficiency in
β-hexosaminidase A activity and lacking effective therapies. Using a Sandhoff disease (SD) …

BACKGROUND & AIMS: To investigate the peripheral sensory effects of repeated stress in
patients with postinfectious irritable bowel syndrome (IBS), we tested whether stress following …

Professional antigen-presenting cells (APCs) play a crucial role in initiating immune
responses. Under pathological conditions, epithelial cells at mucosal surfaces act as …

Questions remain concerning the long-term efficacy, safety, and site(s) of transgene expression
following adeno-associated vector (AAV) therapy. We report a long-term follow-up of 8 (…

Background: Oesophagitis is characterised by basal cell hyperplasia and activated
eosinophils, which release mediators including major basic protein (MBP). MBP and its mimetic …

Although use of the internal thoracic artery (ITA) for coronary artery bypass grafting results
in superior graft patency and improved patient survival, our initial clinical observations …

Salmonella typhimurium is a major cause of diarrhea and causes significant morbidity and
mortality worldwide and perturbations of the gut microbiota are known to increase …

Alveolar soft part sarcoma (ASPS) is a rare malignancy that, since its initial description,
remains a neoplasm of uncertain histogenesis. The disease‐defining molecular event …

The RET receptor tyrosine kinase mediates cell proliferation, survival and migration in
embryogenesis and is implicated in the transformation and tumour progression in multiple cancers…