Reactive astrocytosis develops in many neurologic diseases, including epilepsy. Astrocytotic
contributions to pathophysiology are poorly understood. Studies examining this are …

Inherited metabolic disorders that affect the central nervous system typically result in pathology
throughout the brain; thus, gene therapy strategies need to achieve widespread delivery. …

Following synthesis, integral membrane proteins dwell in the endoplasmic reticulum (ER)
for variable periods that are typically rate limiting for plasma membrane delivery. In neurons, …

Lentiviral vectors have proven to be promising tools for transduction of central nervous system
(CNS) cells in vivo and in vitro. In this study, CNS transduction patterns of lentiviral vectors …

Inverting papilloma of the nose and paranasal sinuses is a benign disease with malignant
potential. This disease is characterized by multiple recurrences, especially after minimal …

Aggregation and deposition of the 40–42-residue amyloid β-protein (Aβ) are early and
necessary neuropathological events in Alzheimer's disease. An understanding of the molecular …

We sought to evaluate the potential of C17.2 neural progenitor cells (NPCs) engineered to
secrete glial cell line‐derived neurotrophic factor (GDNF) to survive, differentiate and promote …

In the nervous system, astrocytes express different ratios of the two glial glutamate
transporters, glutamate transporter subtype 1 (GLT‐1) and glutamate/aspartate transporter (GLAST), …

Objectives/Hypothesis Tissue engineering laboratories are attempting to create neocartilage
that could serve as an implant material for structural support during reconstructive surgery. …

OBJECTIVES: Cartilage grafts for reconstructive surgery may someday be created from
harvested autologous chondrocytes that are expanded and seeded onto biodegradable …