Background The Randomized Aldactone Evaluation Study (RALES) demonstrated that
spironolactone significantly improves outcomes in patients with severe heart failure. Use of …

Background Because of a belief that the use of cellular telephones while driving may cause
collisions, several countries have restricted their use in motor vehicles, and others are …

Subjects were exposed to two aversive experiences: in the short trial, they immersed one
hand in water at 14 C for 60 s; in the long trial, they immersed the other hand at 14 C for 60 s, …

Patients' memories of painful medical procedures may influence their decisions about future
treatments, yet memories are imperfect and susceptible to bias. We recorded in real-time the …

Functional status measurements are often difficult to interpret because small differences may
be statistically significant but not clinically significant. How much does the Six Minute Walk …

Background The level of staffing in hospitals is often lower on weekends than on weekdays,
despite a presumably consistent day-to-day burden of disease. It is uncertain whether in-…

Background Maternal placental syndromes, including the hypertensive disorders of pregnancy
and abruption or infarction of the placenta, probably originate from diseased placental …

ContextDrug-drug interactions are a preventable cause of morbidity and mortality, yet their
consequences in the community are not well characterized.ObjectiveTo determine whether …

Methods Methods The 7 leading scientific journals by citation impact factor (Journal Citation
Reports, Thomson Scientific, Philadelphia, Pa, 2004) that regularly publish original animal …

Background Patients can have several illnesses concurrently, yet some of these diseases
may be neglected if one problem consumes attention. We conducted a population-based …