Background The benefit of coronary-artery revascularization before elective major vascular
surgery is unclear. Methods We randomly assigned patients at increased risk for …

Background Intravenous sodium bicarbonate and oral acetylcysteine are widely used to
prevent acute kidney injury and associated adverse outcomes after angiography without …

Background: In the ISCHEMIA trial (International Study of Comparative Health Effectiveness
with Medical and Invasive Approaches), an initial invasive strategy did not significantly …

Aims The predictors and outcomes of patients with a peri-operative elevation in cardiac
troponin I above the 99th percentile of normal following an elective vascular operation have not …

Distal to a chronic coronary artery stenosis, structural remodeling of the microvasculature
occurs. The microvascular functional changes distal to the stenosis have not been studied in …

The molecular basis of myocardial adaptation to ischemia and reperfusion is poorly
understood. It is thought that nuclear proto-oncogenes act as third messengers, converting …

Activation of AMP-activated protein kinase (AMPK)-α2 protects the heart against pressure
overload–induced heart failure in mice. Although metformin is a known activator of AMPK, it is …

BACKGROUND: The aim of the study was to examine the relationship between preoperative
pulmonary function and outcomes after cardiac surgery. METHODS: We performed …

The Coronary Artery Revascularization Prophylaxis (CARP) study showed no survival benefit
with preoperative coronary artery revascularization before elective vascular surgery. The …

BACKGROUND: Among patients in need of coronary revascularization before an elective
vascular operation, the value of coronary artery bypass grafting (CABG) versus percutaneous …