During mouse meiosis, the early prophase RAD51/DMC1 recombination protein sites, which
are associated with the chromosome cores and which serve as markers for ongoing DNA-…

We describe the discovery of UNC1215, a potent and selective chemical probe for the
methyllysine (Kme) reading function of L3MBTL3, a member of the malignant brain tumor (MBT) …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nucleocapsid (N) protein
is essential for viral replication, making it a promising target for antiviral drug and vaccine …

COVID-19 mortality is primarily driven by abnormal alveolar fluid metabolism of the lung,
leading to fluid accumulation in the alveolar airspace. This condition is generally referred to as …

Antibodies are used in multiple cell biology applications, but there are no standardized methods
to assess antibody quality—an absence that risks data integrity and reproducibility. We …

Nuclear receptor-binding SET domain-containing 2 (NSD2) is the primary enzyme responsible
for the dimethylation of lysine 36 of histone 3 (H3K36), a mark associated with active …

The apolipoprotein B messenger RNA editing enzyme, catalytic polypeptide-like (APOBEC)
family of single-stranded DNA (ssDNA) cytosine deaminases provides innate immunity …

Chromatin regulation is driven by multicomponent protein complexes, which form functional
modules. Deciphering the components of these modules and their interactions is central to …

The RNA polymerase II (RNAPII) C-terminal domain (CTD) heptapeptide repeats (1-YSPTSPS-7)
undergo dynamic phosphorylation and dephosphorylation during the transcription …

Programmed double-strand breaks at prophase of meiosis acquire immunologically
detectable RAD51-DMC1 foci or early nodules (ENs) that are associated with developing …