Gamma-linolenic acid (GLA, 18:3n-6) is an omega-6 (n-6), 18 carbon (18C-) polyunsaturated
fatty acid (PUFA) found in human milk and several botanical seed oils and is typically …

Background The endothelial glycocalyx layer (EGL) is a key regulator of vascular
permeability, cell adhesion, and inflammation. The EGL is primarily composed of syndecan-1, …

Secondary lymphatic valves are essential for minimizing backflow of lymph and are
presumed to gate passively according to the instantaneous trans-valve pressure gradient. We …

BACKGROUND We hypothesized that patients with pelvic fractures and hemorrhage admitted
during daytime hours were undergoing interventional radiology (IR) earlier than those …

The carbohydrate hyaluronan (or hyaluronic acid, HA) is found in all human tissues and
biofluids where it has wide-ranging functions in health and disease that are dictated by both its …

BACKGROUND The classic definition of massive transfusion, 10 or more units of red blood
cells (RBCs) in 24 hours, has never been demonstrated as a valid surrogate for severe …

BACKGROUND Thrombin is the central coagulation protease that activates clotting proteins,
triggers platelet aggregation, and converts fibrinogen to fibrin. Relationships between …

Background: Lymph flow depends on both the rate of lymph production by tissues and the
extent of passive and active pumping. Here we aim to characterize the passive mechanical …

Hyaluronan (or hyaluronic acid, HA) is a ubiquitous molecule that plays critical roles in
numerous physiological functions in vivo, including tissue hydration, inflammation, and joint …

The lymphatic system is an extensive vascular network featuring valves and contractile
walls that pump interstitial fluid and plasma proteins back to the main circulation. Immune …