Background: New hepatitis C virus (HCV) therapies report cure rates of ~90% but are expensive.
Identification of predictors for treatment failure could help decrease health care costs, …

Rationale Lysosomal associated membrane protein type-2 (LAMP-2) is a highly conserved,
ubiquitous protein that is critical for autophagic flux. Loss of function mutations in the LAMP-2 …

Background Adolescent obesity is considered a public health challenge. Sleeve gastrectomy
(SG) may be considered a safe option for treatment of adolescent obesity. This study aimed …

Purpose With improving short-term mortality in acute respiratory distress syndrome (ARDS),
understanding survivors’ posthospitalisation outcomes is increasingly important. However, …

… For all i ∈ I and l ∈ L, we let ρi,l represents the fraction of relief supplies preprepositioned
… of type l occurs. For all t ∈ T , i ∈ N, and l ∈ L, we let random parameter Mt,i,l represent the …

Rationale: Lysosomal associated membrane protein type-2 (LAMP-2) is a highly conserved,
ubiquitous proteinthat is critical for autophagic flux. Loss of function mutations in the LAMP-2 …

Tyrosyl-DNA phosphodiesterase 1 (TDP1) is an enzyme crucial for cleavage of the covalent
topoisomerase 1-DNA complex, an intermediate in DNA repair. TDP1 plays a role in …

CD40L, a key regulator of the immune system, was studied as both a targeting ligand and a
molecular adjuvant in nucleoprotein (NP)-based host defense against influenza in mouse …

Chromatin compaction mediates progenitor to post-mitotic cell transitions and modulates
gene expression programs, yet the mechanisms are poorly defined. Snf2h and Snf2l are ATP-…

Danon disease (DD) is a rare X-linked autophagic vacuolar myopathy associated with
multiorgan dysfunction, including the heart, skeletal muscle, and liver. There are no specific …