Background Colorectal cancer can arise through two distinct mutational pathways: microsatellite
instability or chromosomal instability. We tested the hypothesis that colorectal cancers …

Background: Although second primary cancers are a leading cause of death among men
with testicular cancer, few studies have quantified risks among long-term survivors. Methods: …

Context Second cancer is the leading cause of death in long-term survivors of Hodgkin disease
(HD), with exceptionally high risks of breast cancer among women treated at a young age…

Background: Lung cancer is a frequent cause of death in patients cured of Hodgkin's disease,
but the contributions of chemotherapy, radiotherapy, and smoking are not well described. …

A case-control study of male-female differences in cigarette smoking and lung cancer was
conducted during 1981–1985 in Toronto, St. Catharine's, and Niagara Falls, Ontario, Canada. …

Background: We have quantified the site-specific risk of second malignant neoplasms among
nearly 29 000 survivors (⩾1 year) of testicular cancer, taking into account the histologic …

Background: Many women develop breast cancer after treatment for Hodgkin lymphoma (HL)
at a young age. We estimated this future risk, taking into account age and calendar year of …

Background: Cyclophosphamide is an established bladder carcinogen, but few studies have
examined the relationship between dose and effect. The largest analysis to date included …

Background Platinum-based chemotherapy is the cornerstone of modern treatment for ovarian,
testicular, and other cancers, but few investigations have quantified the late sequelae of …

PURPOSE: To quantify the risk of second cancers among long-term survivors of Hodgkin’s
disease (HD) diagnosed before 21 years of age and to explore sex-, age-, and site-related …